Global burden of mental disorders in 204 countries and territories results from the Global Burden of Disease Study 2021

doi:10.5498/wjp.v15.i8.106887

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World Journal of Psychiatry

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World J Psychiatry. Aug 19, 2025; 15(8): 106887
Published online Aug 19, 2025. doi: 10.5498/wjp.v15.i8.106887

Table 1 Incidence of mental disorders, and percentage change of age-standardized rates by global burden of disease region

World region	Number of incidence cases in 1990	ASIR per 100000 in 1990	Number of incidence cases in 2019	ASIR per 100000 in 2019	Number of incidence cases in 2021	ASIR per 100000 in 2021	1990-2021¹	2019-2021¹
Global	241360893.59	4737.974 (4278.42, 5368.46)	374348204.98	4703.23 (4247.84, 5334.32)	444397716.12	5459.77 (4873.72, 6241.42)	15.23 (12.97, 17.60)	16.08 (14.22, 18.00)
Low SDI	23709008.99	6143.20 (5397.31, 7113.59)	50605025.34	5861.74 (5164.94, 6762.84)	60311400.61	6514.44 (5697.32, 7557.96)	6.04 (1.97, 9.92)	11.13 (6.80, 15.31)
Low-middle SDI	55310181.11	5665.99 (5054.42, 6486.09)	95238869.07	5330.20 (4759.97, 6080.08)	116086947.49	6216.11 (5495.21, 7144.06)	9.709 (5.377, 14.245)	16.62 (12.05, 20.87)
Middle SDI	68734613.80	4227.592 (3825.97, 4770.91)	107423073.71	4260.84 (3870.13, 4789.73)	126831832.25	4920.13 (4442.47, 5540.26)	16.38 (14.01, 18.91)	15.47 (12.91, 18.23)
High-middle SDI	48995901.86	4539.15 (4134.81, 5057.42)	61968786.98	4326.48 (3937.12, 4843.04)	70163004.56	4917.24 (4414.74, 5538.76)	8.32 (4.11, 12.48)	13.65 (10.03, 17.57)
High SDI	44390979.50	4835.38 (4415.93, 5367.04)	58825036.24	5270.11 (4760.83, 5950.82)	70659767.83	6423.82 (5760.36, 7244.81)	32.85 (28.39, 37.98)	21.89 (18.63, 25.34)
Andean Latin America	1464494.28	4243.82 (3782.93, 4830.68)	2604676.88	4070.36 (3639.89, 4687.07)	3583280.08	5347.37 (4595.75, 6241.11)	26.00 (13.96, 40.20)	31.37 (18.58, 45.39)
Australasia	1418294.61	6766.65 (6089.73, 7556.67)	2019342.19	6827.27 (6066.05, 7815.30)	2231887.29	7325.01 (6147.35, 8863.53)	8.25 (-7.22, 26.30)	7.29 (-7.81, 24.20)
Caribbean	1948481.12	5803.64 (5154.29, 6668.33)	2584766.49	5297.02 (4665.54, 6132.14)	3122929.251	6307.79 (5409.94, 7386.54)	8.68 (0.29, 18.08)	19.08 (10.54, 29.18)
Central Asia	2741842.19	4448.91 (3934.43, 5055.71)	3873032.28	4278.75 (3794.93, 4893.24)	4684860.78	4994.54 (4299.53, 5811.01)	12.26 (3.84, 22.01)	16.72 (7.27, 26.71)
Central Europe	5045588.24	3802.67 (3437.13, 4277.96)	4728493.55	3478.35 (3142.74, 3913.23)	5712469.56	4364.02 (3862.89, 4955.29)	14.762 (8.98, 20.94)	25.46 (19.97, 32.21)
Central Latin America	6437675.11	4458.02 (4017.97, 5047.77)	12460247.31	4854.37 (4375.38, 5478.64)	15343630.39	5849.19 (5223.78, 6692.60)	31.21 (25.97, 36.95)	20.49 (15.88, 25.13)
Central sub-Saharan Africa	3527045.57	8271.15 (7096.42, 9844.93)	8374613.58	8023.19 (6936.78, 9482.64)	9791078.54	8706.11 (7166.05, 10620.38)	5.25 (-6.92, 20.21)	8.51 (-4.18, 22.48)
East Asia	42832652.44	3537.32 (3214.57, 3939.56)	55224835.55	3342.22 (3058.38, 3686.25)	56340544.97	3340.99 (3025.52, 3712.33)	-5.55 (-9.83, -0.99)	-0.04 (-3.38, 3.83)
Eastern Europe	12459215.15	5103.58 (4537.33, 5713.92)	11408783.79	4720.44 (4200.09, 5309.38)	14023793.62	6014.06 (5286.17, 6838.01)	17.84 (12.25, 24.82)	27.40 (21.45, 34.99)
Eastern sub-Saharan Africa	9655720.56	7014.94 (6190.74, 8082.61)	20759152.74	6673.86 (5917.56, 7655.79)	25372933.20	7528.26 (6567.61, 8690.75)	7.31 (1.96, 13.44)	12.80 (6.73, 18.94)
High-income Asia Pacific	5924026.78	3276.75 (2999.91, 3622.88)	6465420.28	3377.09 (3095.76, 3745.76)	7350004.69	3950.35 (3551.76, 4462.44)	20.55 (14.32, 27.21)	16.97 (11.27, 23.02)
High-income North America	15096975.24	5205.05 (4701.26, 5826.75)	23451454.02	6417.86 (5818.29, 7228.01)	29528972.62	8145.60 (7295.06, 9182.34)	56.49 (50.04, 63.07)	26.92 (22.34, 32.28)
North Africa and Middle East	19331359.71	6334.31 (5557.62, 7364.13)	38717767.93	6400.93 (5545.95, 7463.87)	46242809.91	7336.22 (6303.06, 8574.72)	15.81 (10.24, 21.48)	14.61 (9.56, 20.12)
Oceania	228321.57	3774.89 (3318.00, 4378.00)	464450.15	3692.82 (3252.82, 4283.07)	527863.68	3981.68 (3330.94, 4801.24)	5.47 (-7.42, 20.21)	7.82 (-5.91, 23.24)
South Asia	52393026.91	5730.80 (5137.66, 6540.88)	91516789.32	5207.73 (4654.64, 5906.19)	112893184.39	6134.14 (5462.68, 7015.18)	7.03 (3.11, 11.72)	17.78 (13.41, 22.41)
Southeast Asia	14009335.03	3167.44 (2844.43, 3579.11)	21721271.57	3104.21 (2785.32, 3485.37)	26764622.17	3720.30 (3311.08, 4216.65)	17.45 (13.45, 22.26)	19.84 (15.48, 24.81)
Southern Latin America	2463407.05	4980.19 (4497.42, 5639.55)	3207725.50	4662.74 (4229.63, 5239.88)	4018236.66	5775.16 (4900.07, 6788.32)	15.96 (2.41, 29.82)	23.85 (10.52, 37.83)
Southern sub-Saharan Africa	2524562.52	5700.30 (5128.44, 6492.29)	4273340.97	5686.72 (5105.84, 6454.32)	5531244.66	7052.85 (6182.21, 8128.01)	23.72 (16.52, 32.01)	24.02 (16.69, 32.11)
Tropical Latin America	8655965.15	6083.62 (5503.83, 6856.24)	13484022.70	5692.05 (5193.08, 6297.35)	17191336.65	7097.75 (6342.27, 8053.77)	16.670 (10.49, 23.24)	24.69 (17.64, 32.02)
Western Europe	24941474.43	6120.52 (5603.73, 6762.26)	27848759.86	5984.89 (5352.55, 6812.56)	32649490.49	7218.40 (6356.58, 8319.83)	17.938 (11.02, 25.75)	20.61 (14.83, 26.97)
Western sub-Saharan Africa	8261429.89	5614.08 (4983.27, 6430.13)	19159258.26	5405.37 (4793.92, 6170.41)	21492542.48	5657.36 (4960.75, 6496.80)	0.771 (-3.21, 4.65)	4.66 (0.46, 8.60)

¹Percentage change of age-standardized incidence rate.

ASIR: Age-standardized incidence rate; SDI: Socio-demographic index.

Citation: Mao QS, Guo YX, Tian XL, Zhao HL, Kong YZ. Global burden of mental disorders in 204 countries and territories results from the Global Burden of Disease Study 2021. World J Psychiatry 2025; 15(8): 106887
URL: https://www.wjgnet.com/2220-3206/full/v15/i8/106887.htm
DOI: https://dx.doi.org/10.5498/wjp.v15.i8.106887