DNA methylation regulates the extinction of fear memory

Figure 2 DNA methyltransferase-3A and dendritic spine density changed after RG108 injection. A: Experimental procedures; B: Significant decreased in the density of DNA methyltransferase-α (Dnmt3a)-positive cells in the RG108 group, compared to vehicle group (n = 4 mice, at least 3 sections per mouse; unpaired t-test, T₆ = 3.617, P < 0.05); C: Sample images of Dnmt3a staining; D: Sample images of Golgi staining; E: The dendritic spine density was decreased in RG108 group (axons from at least 3 mice per group, unpaired test, T₁₆ = 3.844, P < 0.01). ^aP < 0.05; ^bP < 0.01; ^cP< 0.001.