Neuropsychiatric symptoms in the context of hemodynamic disruption during septic shock

Table 4 Inflammatory factors and neurotransmitter profiles

Parameter	Sepsis group (n = 86)	Septic shock group (n = 46)	P value
Inflammatory factors
IL-6 (pg/mL)	125.4 ± 30.2	250.8 ± 50.4	< 0.001
TNF-α (pg/mL)	85.6 ± 15.2	150.2 ± 25.3	< 0.001
hs-CRP (mg/L)	45.3 ± 10.2	80.5 ± 15.1	< 0.001
IL-1β (pg/mL)	20.5 ± 5.1	35.2 ± 7.3	< 0.001
Neurotransmitter levels
Serotonin (ng/mL)	150.2 ± 20.3	120.5 ± 18.2	< 0.001
Dopamine (ng/mL)	80.5 ± 12.3	60.2 ± 10.5	< 0.001
Norepinephrine (ng/mL)	60.3 ± 8.5	45.2 ± 7.8	< 0.001
Glutamate (µM)	10.5 ± 1.5	12.8 ± 2.0	< 0.001
GABA (µM)	8.2 ± 1.2	6.5 ± 1.0	< 0.001

Data are presented as mean ± SD. IL: Interleukin; TNF-α: Tumor necrosis factor-alpha; hs-CRP: High-sensitivity C-reactive protein; GABA: Gamma-aminobutyric acid.