Correlation between depressive-like behavior and gut microbiota in mice with hypothyroidism

Figure 5 Relative abundance of gut microbiota in hypothyroidism mice. A: At the phylum level, microbiota composition differs between hypothyroid group (HO) and control groups; B: At the genus level, notable changes in bacterial abundance were observed; C: LEfSe analysis identified specific differential bacteria associated with the HO group in the cladogram; D: Linear discriminant analysis scores confirm significant differences in taxa within the HO group; E: The correlation heatmap illustrates associations between differential bacteria and behavioral/physiological parameters, with certain bacteria (e.g., Bilophila and Psychrobacter) associated with depression-like behaviors. ^aP < 0.05, ^bP < 0.01. HO: Hypothyroid group.