Clinical manifestations of anxiety and depression in sepsis-associated encephalopathy and multi-omics identification of cluster of differentiation 38 as an early biomarker

Figure 5 Metabolite enrichment analysis and identification of key metabolites. A: Pathway analysis. The horizontal axis represents significance, and the vertical axis represents pathway names; B: Metabolite coefficient plot. The horizontal axis represents the logarithmic value of λ; the vertical axis represents the regression coefficient. The curve illustrates the relationship between the regression coefficient of the variable (metabolite) and λ; C: Cross-validation error plot. The horizontal axis represents log (λ) values, and the vertical axis represents degrees of freedom. The dashed line represents the λ corresponding to the minimum error mean. The numbers above the graph represent the number of metabolites corresponding to different λ values; D: Union of results from two machine learning algorithms; E: Correlation heatmap between key metabolites and key proteins. The horizontal axis represents proteins, the vertical axis represents metabolites, and the numbers in the figure represent the correlation coefficients between them. ^cP < 0.001. LASSO: Least absolute shrinkage and selection operator.