Clinical manifestations of anxiety and depression in sepsis-associated encephalopathy and multi-omics identification of cluster of differentiation 38 as an early biomarker

Table 7 Diagnostic value of cluster of differentiation 38, neuron-specific enolase, lactate, procalcitonin, and combined markers for sepsis-associated encephalopathy

	Cut-off	AUC (95%CI)	P value	Sensitivity	Specificity
CD38	≥ 8.18	0.842 (0.739-0.945)	< 0.001	0.759	0.862
NSE	≥ 17.52	0.720 (0.589-0.851)	0.004	0.517	0.862
Lactate	≥ 1.75	0.693 (0.555-0.830)	0.012	0.862	0.483
PCT	≥ 0.31	0.692 (0.556-0.828)	0.012	0.828	0.552
Probabilities	≥ 0.396	0.904 (0.826-0.982)	< 0.001	0.862	0.862

NSE: Neuron-specific enolase; PCT: Procalcitonin; CD: Cluster of differentiation; AUC: Area under the curve; CI: Confidence interval.