Modulating oral microbiota ameliorates hypobaric hypoxia-induced anxiety- and depression-like behaviors in mice

Figure 7 Supplementation with Lactobacillus complex alleviates anxiety and depression-like behavior in one day of hypobaric hypoxia exposure mice. A: Schematic diagram of oral supplementation with Lactobacillus complex in mice; B: Lactobacillus supplementation experiment paradigm; C: Total distance for each group in the open field test (n = 8); D: Central distance for each group in the open field test (n = 8); E: Entries to the central zone for each group in the open field test (n = 8); F: Time spend in the open arm for each group in the elevated plus maze test (n = 8); G: Entries to the open arm for each group in the elevated plus maze test (n = 8); H: Time spend in the close arm for each group in the elevated plus maze test (n = 8); I: Immobility latency for each group in the forced swim test (n = 8); J: Immobility time or each group in the forced swim test (n = 8); K: Cluster heat-map for open field test across groups; L: Cluster heat-map for elevated plus maze across groups. NS: No significance; Con: Control group; HH1: One day of hypobaric hypoxia exposure; HH: Hypobaric hypoxia; OFT: Open field test; EPM: Elevated plus maze; FST: Forced swim test.