Diagnostic dynamic contrast-enhanced magnetic resonance imaging blood-brain barrier assessment combined with plasma biomarkers for mild cognitive impairment

Table 4 Comparison of blood-brain barrier permeability among three groups, mean ± SD

Ktrans	Right					Left
	Control group (n = 55)	na-MCI group (n = 50)	a-MCI group (n = 52)	F value	P value	Control group (n = 55)	na-MCI group (n = 50)	a-MCI group (n = 52)	F value	P value
Frontal lobe	0.01 ± 0.01	0.13 ± 0.01a,1	0.03 ± 0.01a,1,2	2126	< 0.0001	0.09 ± 0.01	0.19 ± 0.02a,1	0.02 ± 0.01a,1,2	1901	< 0.0001
Temporal lobe	0.05 ± 0.02	0.10 ± 0.02a,1	0.08 ± 0.02a,1,2	83.51	< 0.0001	0.02 ± 0.01	0.11 ± 0.01a,1	0.02 ± 0.01a,2	1380	0.867
Hippocampal area	0.02 ± 0.01	0.06 ± 0.01a,1	0.13 ± 0.03a,1,2	451.6	< 0.0001	0.01 ± 0.01	0.03 ± 0.01a,1	0.09 ± 0.03a,1,2	251.0	< 0.0001

^aP < 0.05.

¹P vs control group.

²P vs non-amnestic mild cognitive impairment group.

a-MCI: Amnestic mild cognitive impairment; na-MCI: Non-amnestic mild cognitive impairment.