Diagnostic dynamic contrast-enhanced magnetic resonance imaging blood-brain barrier assessment combined with plasma biomarkers for mild cognitive impairment

doi:10.5498/wjp.v15.i6.103661

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World Journal of Psychiatry

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World J Psychiatry. Jun 19, 2025; 15(6): 103661
Published online Jun 19, 2025. doi: 10.5498/wjp.v15.i6.103661

Table 3 Comparison of cerebral blood flow among three groups, mean ± SD

CBF/(mL/100 g/minute)	Right					Left
CBF/(mL/100 g/minute)	Control group (n = 55)	na-MCI group (n = 50)	a-MCI group (n = 52)	F value	P value	Control group (n = 55)	na-MCI group (n = 50)	a-MCI group (n = 52)	F value	P value
Frontal lobe	69.40 ± 3.51	70.72 ± 2.15^a^,¹	53.37 ± 2.58^a^,¹^,²	606.4	< 0.0001	63.34 ± 3.25	59.60 ± 2.27^a^,¹	48.92 ± 2.60^a^,¹^,²	390.5	< 0.0001
Temporal lobe	53.31 ± 1.85	43.40 ± 1.37^a^,¹	47.64 ± 1.42^a^,¹^,²	528.1	< 0.0001	55.66 ± 2.02	51.67 ± 1.62^a^,¹	48.89 ± 1.39^a^,¹^,²	213.7	< 0.0001
Hippocampal head	58.83 ± 2.63	51.38 ± 1.65^a^,¹	48.71 ± 1.94^a^,¹^,²	325.7	< 0.0001	53.77 ± 2.51	49.06 ± 2.20^a^,¹	49.66 ± 2.42^a^,¹	61.72	< 0.0001
Hippocampus	51.32 ± 2.15	50.16 ± 1.40^a^,¹	45.87 ± 2.09^a^,¹^,²	117.8	< 0.0001	49.78 ± 1.94	46.78 ± 1.61^a^,¹	45.10 ± 1.98^a^,¹^,²	87.63	< 0.0001
Cuneus	55.20 ± 2.68	43.33 ± 1.55^a^,¹	43.24 ± 1.64^a^,¹	607.8	< 0.0001	52.23 ± 2.41	41.69 ± 1.09^a^,¹	46.90 ± 1.54^a^,¹^,²	455.1	< 0.0001
Precuneus	52.56 ± 2.36	49.67 ± 1.20^a^,¹	44.74 ± 1.58^a^,¹^,²	256.8	< 0.0001	55.17 ± 2.26	45.37 ± 1.34^a^,¹	43.22 ± 1.50^a^,¹^,²	701.6	< 0.0001
Parietal lobe	49.91 ± 2.23	48.37 ± 1.66^a^,¹	45.13 ± 1.37^a^,¹^,²	97.41	< 0.0001	48.24 ± 1.34	45.61 ± 1.19^a^,¹	42.53 ± 0.98^a^,¹^,²	311.9	< 0.0001
Basal ganglia	70.93 ± 2.38	67.66 ± 1.75^a^,¹	60.67 ± 1.49^a^,¹^,²	394.2	< 0.0001	70.53 ± 2.25	67.42 ± 2.24^a^,¹	64.63 ± 1.74^a^,¹^,²	106.6	< 0.0001
Occipital lobe	47.98 ± 2.28	48.21 ± 1.67	45.46 ± 1.49^a^,¹^,²	35.10	< 0.0001	48.20 ± 1.62	47.61 ± 1.69	45.25 ± 1.23^a^,¹^,²	55.12	< 0.0001

^aP < 0.05.

¹P vs control group.

²P vs non-amnestic mild cognitive impairment group.

CBF: Cerebral blood flow; a-MCI: Amnestic mild cognitive impairment; na-MCI: Non-amnestic mild cognitive impairment.

Citation: Sun L, Xu MR, Zhou CY, Cao SD, Zhang XL, Guan SQ, Sang WX, Li XL. Diagnostic dynamic contrast-enhanced magnetic resonance imaging blood-brain barrier assessment combined with plasma biomarkers for mild cognitive impairment. World J Psychiatry 2025; 15(6): 103661
URL: https://www.wjgnet.com/2220-3206/full/v15/i6/103661.htm
DOI: https://dx.doi.org/10.5498/wjp.v15.i6.103661