Factors influencing anxiety and depression in advanced hepatocellular carcinoma patients and their impact on quality of life

Table 4 Binary logistic regression analysis of hepatocellular carcinoma combined with anxiety

Variable	OR	95%CI	P value
Age (≥ 60 vs < 60)	1.228	1.114-1.514	< 0.001
Sex (male vs female)	1.104	0.925-1.353	0.773
Education (primary & secondary vs senior high school)	1.728	1.139-2.523	0.028
Live alone (yes vs no)	1.193	0.736-1.534	0.951
KPS score (> 80 vs 60-80)	0.888	0.584-0.957	0.012
HAMA score (> 14 vs ≤ 14)	2.038	1.554-2.636	< 0.001
HAMD score (> 8 vs ≤ 8)	1.856	1.336-2.308	< 0.001
Previous liver resection (yes vs no)	1.299	1.163-1.622	0.017
TACE/HAIC (yes vs no)	1.353	1.182-1.811	< 0.001
BCLC stage (C vs B)	1.455	1.187-1.943	< 0.001
Number of tumors (multiple vs single)	2.567	1.893-3.244	0.034
FACT-Hep scores (good vs poor)	0.678	0.473-0.978	< 0.001
Social support (high vs low & moderate)	0.752	0.615-0.977	< 0.001
History of drinking (yes vs no)	2.007	1.483-2.684	< 0.001

OR: Odds ratio; CI: Confidence interval; KPS: Karnofsky performance score; HAMA: Hamilton Anxiety Rating Scale; HAMD: Hamilton Depression Rating Scale; TACE: Transcatheter arterial chemoembolization; HAIC: Hepatic artery infusion chemotherapy; BCLC: Barcelona Clinic Liver Cancer; FACT-Hep: Functional Assessment of Cancer Therapy-Hepatobiliary Questionnaire.