Gut-brain connection in schizophrenia: A narrative review

doi:10.5498/wjp.v15.i5.103751

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May 19, 2025 (publication date) through Jun 10, 2025

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World Journal of Psychiatry

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2220-3206

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World J Psychiatry. May 19, 2025; 15(5): 103751
Published online May 19, 2025. doi: 10.5498/wjp.v15.i5.103751

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Figure 2 Tryptophan metabolism. Tryptophan can be metabolized into serotonin or kynurenine (this process is influenced by gut microbiota and inflammation/stress). Inflammation or stress shifts tryptophan metabolism toward the kynurenine pathway. Serotonin helps in mood regulation, sleep cycle, and cognitive function. Quinolinic acid is a neurotoxin, while kynurenic acid is neuroprotective.

Citation: Iqbal A, Bokhari SFH, Rehman MU, Faizan Sattar SM, Bakht D, Dost W, Basit A. Gut-brain connection in schizophrenia: A narrative review. World J Psychiatry 2025; 15(5): 103751
URL: https://www.wjgnet.com/2220-3206/full/v15/i5/103751.htm
DOI: https://dx.doi.org/10.5498/wjp.v15.i5.103751