Review
Copyright ©The Author(s) 2025.
World J Psychiatry. May 19, 2025; 15(5): 103751
Published online May 19, 2025. doi: 10.5498/wjp.v15.i5.103751
Figure 2
Figure 2 Tryptophan metabolism. Tryptophan can be metabolized into serotonin or kynurenine (this process is influenced by gut microbiota and inflammation/stress). Inflammation or stress shifts tryptophan metabolism toward the kynurenine pathway. Serotonin helps in mood regulation, sleep cycle, and cognitive function. Quinolinic acid is a neurotoxin, while kynurenic acid is neuroprotective.