Correlation between mild behavioral impairment and peripheral blood biomarkers in patients with mild cognitive impairment

Table 2 Demographic characteristics and cognitive and behavioral features of non-mild behavioral impairment and mild behavioral impairment groups in mild cognitive impairment, mean ± SD/n (%)

Characteristic	MCI (n = 105)		t/χ2/K-W	P value
	MBI- (n = 89)	MBI+ (n = 16)
Age (years)	77.5 ± 8.1	75.3 ± 6.1	0.997	0.321
Male	31 (34.8)	7 (43.8)	0.467	0.494
Education years median (P25, P75)	10 (6, 14)	12 (9.5, 12)	0.901	0.367
Bereavement	22 (24.7)	3 (13.8)	0.266	0.606
Current smoking	4 (4.5)	3 (18.8)	5.328	0.058
Current drinking	11 (12.4)	4 (25.0)	3.413	0.171
Hypertension	30 (33.7)	11 (68.8)	6.997	0.008
Coronary heart disease	24 (27.0)	7 (43.8)	1.836	0.175
Diabetes	20 (22.5)	6 (37.5)	1.644	0.200
Hyperlipidemia	23 (25.8)	6 (37.5)	0.922	0.337
SCD	73 (82.0)	16 (100)	3.394	0.065
MMSE median (P25, P75)	25 (24, 27)	25 (23.3, 27)	0.250	0.803
MoCA median (P25, P75)	22 (19, 24)	23 (19.5, 24)	0.405	0.686
CDT median (P25, P75)	3 (2, 4)	3.5 (2, 4)	0.195	0.845
BNT (points)	22.8 ± 4.5	23.8 ± 3.2	0.839	0.403
DST (points)	8.5 ± 2.7	8.3 ± 2.0	0.227	0.821
MBI total score median (P25, P75)	0 (0, 2)	9.5 (7.5, 12.8)	6.322	< 0.001
FAQ median (P25, P75)	0 (0, 2)	1 (0, 4.8)	2.042	0.041

Independent sample t-test for variable of normal distribution, Mann-Whitney U for variable of non-normal distribution, χ² test for categorical variables. MBI: Mild behavioral impairment; MCI: Mild cognitive impairment; SCD: Subjective cognitive impairment; MMSE: Mini-mental state examination; MoCA: Montreal cognitive assessment; CDT: Clock drawing test; BNT: Boston naming test; DST: Digit span test; P₂₅: Lower quartile; P₇₅: Upper quartile; FAQ: Functional activities questionnaire.