Correlation between mild behavioral impairment and peripheral blood biomarkers in patients with mild cognitive impairment

doi:10.5498/wjp.v15.i5.103256

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World Journal of Psychiatry

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World J Psychiatry. May 19, 2025; 15(5): 103256
Published online May 19, 2025. doi: 10.5498/wjp.v15.i5.103256

Table 1 Demographic, cognitive, and behavioral characteristics of healthy older adult and mild cognitive impairment populations, n (%)

Characteristic	HOA (n = 136)	MCI (n = 105)	t/χ²/K-W	P value
Age (years, mean ± SD)	71.8 ± 8.1	77.1 ± 7.9	5.160	< 0.001
Male	45 (33.1)	38 (36.2)	0.253	0.615
Years of education median (P₂₅, P₇₅)	12 (9, 14)	10 (7, 13.5)	1.305	0.192
Bereavement	29 (21.3)	25 (23.8)	0.211	0.646
Smoking history	6 (4.4)	7 (6.7)	0.606	0.738
Drinking history	16 (11.8)	15 (14.3)	1.987	0.370
Hypertension	48 (35.3)	41 (39.0)	0.358	0.549
Coronary heart disease	26 (19.1)	31 (29.5)	3.553	0.059
Diabetes	18 (13.2)	26 (24.8)	5.275	0.022
Hyperlipidemia	40 (29.4)	29 (27.6)	0.093	0.760
SCD (yes, cases)	109 (80.1)	89 (84.8)	0.861	0.354
MMSE median (P₂₅, P₇₅)	28 (28, 29)	25 (24, 27)	11.048	< 0.001
MoCA median (P₂₅, P₇₅)	27 (26, 28)	23 (19, 24)	11.862	< 0.001
CDT median (P₂₅, P₇₅)	4 (4, 4)	3 (2, 4)	5.780	< 0.001
BNT median (P₂₅, P₇₅)	26 (23, 27)	24 (21, 26)	4.129	< 0.001
DST median (P₂₅, P₇₅)	10 (8, 11)	8 (6, 10)	4.271	< 0.001
MBI total score median (P₂₅, P₇₅)	0 (0, 2)	0 (0, 3)	2.223	0.026
MBI > 1	50 (36.8)	50 (47.6)	2.876	0.090
MBI > 6.5	6 (4.4)	16 (15.3)	7.262	0.007
Decreased motivation > 0	14 (10.3)	21 (20.2)	4.635	0.031
Emotional dysregulation	17 (12.5)	20 (19.2)	2.047	0.152
Impulse dyscontrol	39 (28.7)	51 (49.4)	5.063	0.025
Social inappropriateness	1 (0.7)	5 (4.8)	4.010	0.045
Abnormal perception or thought content
FAQ median (P₂₅, P₇₅)	0 (0, 0)	0 (0, 2)	3.372	0.001

Independent sample t-test for variable of normal distribution, Mann-Whitney U for variable of non-normal distribution, χ² test for categorical variables. HOA: Healthy old adults; MCI: Mild cognitive impairment; SCD: Subjective cognitive impairment; MMSE: Mini-mental state examination; MoCA: Montreal cognitive assessment; CDT: Clock drawing test; BNT: Boston naming test; DST: Digit span test; MBI: Mild behavioral impairment; P₂₅: Lower quartile; P₇₅: Upper quartile; FAQ: Functional activities questionnaire.

Citation: Liang W, Wang L, Song M, Geng H, Jing XY, Li W, Huo YX, Huang AQ, Wang XY, An CX. Correlation between mild behavioral impairment and peripheral blood biomarkers in patients with mild cognitive impairment. World J Psychiatry 2025; 15(5): 103256
URL: https://www.wjgnet.com/2220-3206/full/v15/i5/103256.htm
DOI: https://dx.doi.org/10.5498/wjp.v15.i5.103256