Selecting an appropriate stress model of depression in rodents

Figure 6 Maternal separation model/sleep interruption model. A: Maternal separation model. The model involves separating the offspring from the mother for a certain period of time. This can be achieved by placing the offspring in a separate cage or exposing them to a different environment. The purpose of this model is to simulate the effects of maternal separation on the behavior, physiology, and development of the offspring and to study the impact of early environmental factors on the offspring; B: Sleep interruption model. The model, on the other hand, disrupts the normal sleep patterns of rodents. This can be done by periodically waking them up or exposing them to disruptive stimuli, preventing them from achieving deep and uninterrupted sleep. The objective of this model is to investigate the effects of sleep deprivation or sleep interruption on the health, cognition, and behavior of rodents.