Selecting an appropriate stress model of depression in rodents

Figure 5 Chronic unpredictable mild stress model. In this model, animals are continuously exposed to multiple mild stressors that may represent ongoing small challenges in daily life. These stressors may include short-term mild electric shocks, wetting of bedding, tilting cage position, removing bedding, tail clipping, fasting, or water deprivation. Compared to the chronic unpredictable stress model, the stressors in this model are milder and more difficult to predict.