Correlation between anxiety-depression disorders and brain structural connectivity abnormalities after subarachnoid hemorrhage

Figure 4 Regional brain injury assessment by multi-sequence magnetic resonance imaging in experimental subarachnoid hemorrhage. A-E: Frontal lobe imaging in control rats showing normal T2-weighted (A), fluid-attenuated inversion-recovery (B), diffusion weighted imaging (C), apparent diffusion coefficient-region of interest (D), and fractional anisotropy-region of interest (E) appearances; F-J: Corresponding frontal lobe sequences in subarachnoid hemorrhage rats demonstrating hyperintense signals and altered diffusion parameters; K-O: Parietal lobe imaging in control rats with normal signal characteristics across all sequences; P-T: Parietal lobe imaging in subarachnoid hemorrhage rats showing pathological changes including tissue edema and white matter microstructural damage. Color scale in diffusion tensor imaging maps represents diffusion parameters with blue indicating lower values and red-orange indicating higher values. Both frontal and parietal regions exhibit similar injury patterns with regional variations in severity. SAH: Subarachnoid hemorrhage; T2: T2-weighted; FLAIR: Fluid-attenuated inversion-recovery; DWI: Diffusion weighted imaging; ADC: Apparent diffusion coefficient; ROI: Region of interest; FA: Fractional anisotropy.