Relationship between anxiety and depression, dyspnea severity, and pulmonary function in connective tissue disease-associated interstitial lung disease

Table 8 Analysis of mixed-effect model

Fixed effect variable	FVC% (β)	FVC% (P)	DLCO% (β)	DLCO% (P)
Time	0.215	< 0.001	0.187	0.002
GAD-7	-0.412	0.003	-0.389	0.005
PHQ-9	-0.426	0.001	-0.411	0.002
Age	-0.038	0.217	-0.042	0.198
Sex (female = 1)	-0.074	0.532	-0.061	0.578
Systemic sclerosis (yes = 1)	-0.125	0.048	-0.109	0.061

P < 0.05 indicated significant difference. FVC: Forced vital capacity; DLCO: Diffusing capacity of the lungs for carbon monoxide; GAD-7: Generalized anxiety disorder-7; PHQ-9: Patient health questionnaire-9.