Relationship between anxiety and depression, dyspnea severity, and pulmonary function in connective tissue disease-associated interstitial lung disease

doi:10.5498/wjp.v15.i12.110916

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World Journal of Psychiatry

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2220-3206

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Psychiatry. Dec 19, 2025; 15(12): 110916
Published online Dec 19, 2025. doi: 10.5498/wjp.v15.i12.110916

Table 4 Serological indicators

Indicators	At enrollment	Week 4	Week 12	Week 24	χ²/t	P value
CRP (mg/L)	11.25 ± 6.34	8.12 ± 4.27	6.45 ± 3.89	5.87 ± 3.12	8.423	< 0.001
ESR (mm/h)	29.17 ± 12.58	22.84 ± 10.76	18.32 ± 9.65	15.42 ± 9.73	7.125	< 0.001
ANA positive rate (%)	48	46	45	44	1.042	0.307
ENA positive rate (%)	32	30	29	28	0.789	0.446
RF positive rate (%)	35	33	32	31	0.654	0.521
Anti-CCP positive rate (%)	28	27	26	26	0.413	0.675

P < 0.05 indicated significant difference. CRP: C-reactive protein; ESR: Erythrocyte sedimentation rate; ANA: Antinuclear antibody; ENA: Extractable nuclear antibody; RF: Rheumatoid factor; anti-CCP: Anti-cyclic citrullinated peptide antibody.

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Citation: Zhu ZJ, Liu KL, Qu HR. Relationship between anxiety and depression, dyspnea severity, and pulmonary function in connective tissue disease-associated interstitial lung disease. World J Psychiatry 2025; 15(12): 110916
URL: https://www.wjgnet.com/2220-3206/full/v15/i12/110916.htm
DOI: https://dx.doi.org/10.5498/wjp.v15.i12.110916

Zhu ZJ, Liu KL, Qu HR. Relationship between anxiety and depression, dyspnea severity, and pulmonary function in connective tissue disease-associated interstitial lung disease. World J Psychiatry 2025; 15(12): 110916 [PMID: 41357912 DOI: 10.5498/wjp.v15.i12.110916]

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