Sini-Suanzaoren decoction regulates mitochondrial biogenesis mediated by MT-SIRT1 in the treatment of insomnia rats

Figure 3 Effect of Sini-Suanzaoren decoction on body weight, behavioral assessments, serum melatonin levels, hypothalamic ATP content in rats. A: Body weight changes across all groups; B-F: Open field test results; G and H: Elevated plus maze test results; I and J: Pentobarbital-induced sleep test results; K: Serum melatonin content in each group; L: Hypothalamic ATP content in each group. ^aP < 0.001, model group vs control group; ^bP < 0.01, model group vs control group; ^cP < 0.05, positive group vs model group; ^dP < 0.01, positive group vs model group; ^eP < 0.001, positive group vs model group; ^fP < 0.05, Sini-Suanzaoren decoction (SNSZRD) low dose group vs model group; ^gP < 0.01, SNSZRD low dose group vs model group; ^hP < 0.001, SNSZRD low dose group vs model group; ⁱP < 0.05, SNSZRD middle dose group vs model group; ^jP < 0.01, SNSZRD middle dose group vs model group; ^kP < 0.001, SNSZRD middle dose group vs model group; ^lP < 0.05, SNSZRD high dose group vs model group; ^mP < 0.01, SNSZRD high dose group vs model group; ⁿP < 0.001, SNSZRD high dose group vs model group.