Dermatoglyphics and schizophrenia: A comprehensive review of neurodevelopmental biomarkers

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World Journal of Psychiatry

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2220-3206

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World J Psychiatry. Nov 19, 2025; 15(11): 112206
Published online Nov 19, 2025. doi: 10.5498/wjp.v15.i11.112206

Table 1 Summary of twin studies investigating dermatoglyphic abnormalities in psychotic disorders

Study	Location	Twin type	Sample composition	Psychiatric diagnoses	Dermatoglyphic findings
United Kingdom study	Maudsley hospital, United Kingdom	Monozy-gotic	11 normal control pairs; 16 concordant pairs; 9 discordant pairs; 2 triplets (1 concordant, 1 partially affected)	Psychosis	RD and APFC abnormalities mirrored psychosis discordance in discordant twins
United States study	NIMH twin registry, United States	Monozy-gotic	31 discordant pairs; 20 SZ/schizoaffective; 8 bipolar; 3 other psychosis; 19 concordant pairs; 11 SZ/schizoaffective; 3 SZ + schizotypal; 5 mixed psychosis/affective/schizotypal	Schizophrenia, bipolar, schizoaffective, other psychosis	Investigated RD and APFC to test whether dermatoglyphic discordance parallels clinical discordance

APFC: Abnormal palmar flexion creases; RD: Ridge density.

Citation: Bou Farah E, Beydoun K, Nasr L, Chokor Z, Ghanem S, El Fassih I, Akiki S, Moghnieh R, Tlaiss Y, Farhat H. Dermatoglyphics and schizophrenia: A comprehensive review of neurodevelopmental biomarkers. World J Psychiatry 2025; 15(11): 112206
URL: https://www.wjgnet.com/2220-3206/full/v15/i11/112206.htm
DOI: https://dx.doi.org/10.5498/wjp.v15.i11.112206

Bou Farah E, Beydoun K, Nasr L, Chokor Z, Ghanem S, El Fassih I, Akiki S, Moghnieh R, Tlaiss Y, Farhat H. Dermatoglyphics and schizophrenia: A comprehensive review of neurodevelopmental biomarkers. World J Psychiatry 2025; 15(11): 112206 [PMID: 41281513 DOI: 10.5498/wjp.v15.i11.112206]

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