Meta-analysis of factors associated with the incidence of comorbid depression and anxiety in patients with chronic hepatitis B

Table 2 Characteristics of the included studies

Ref.	Country	Study type	Age [(mean ± SD), (min-max), mean (min-max)]	Total sample size	Anxiety incidence (%)	Incidence of depression (%)	Period	Correlation factor
Qin et al[6], 2021	China	Descriptive research	30-71	320	-	75	January 2018 to January 2020	Education level, duration of treatment, number of relapses, complications, nursing satisfaction
Liu et al[7], 2017	China	Cohort study	51.5 (37-79)	501158	-	1.09	2004-2008	Male, age, place of residence, household income, occupation
Huang et al[8], 2019	China	Cohort study	16-70	209	-	29.20	June 2017 to May 2018	Low FT3, total bilirubin
Shi et al[9], 2010	China	Cross-sectional study	16-68	132	-	57.60	1 June 2007 to 31 December 2007	Number of relapses, total score of social support, concern about infection, emotional stability, presence or absence of antiviral therapy, hepatitis score
Kunkel et al[10], 2000	America	Cross-sectional study	24-69	50	-	46	September 1998 to December 1998	Fatigue, serum alanine aminotransferase, serum glutamic oxalacetic aminotransferase
Weinstein et al[11], 2011	America	Retrospective study	43.6 ± 13.2	190	-	3.70	January 2001 to April 2010	Excessive drinking
Hajarizadeh et al[12], 2016	Australia	Cross-sectional study	45 (22-77)	93	76	-	April 2013 to September 2013	Low level of education, life-changing possibilities
Wu et al[13], 2023	China	Case-control study	-	747	-	-	July 2016 to October 2016	Sleep disorder
Ekmen et al[14], 2021	Türkiye	Cross-sectional study	40.58 ± 9.12	182	33.52	55.22	-	Degree of illness, emotional focus
Duan et al[15], 2012	China	Case-control study	52.40 ± 14.23	120	-	-	July 2009 to July 2010	Education, mood, hepatitis grading, sleep quality
Kong et al[16], 2021	China	Cross-sectional study	35.82 (18-66)	188	38.30	33.00	March 2018 to October 2018	Age, female, education level, duration of treatment
Keskin et al[17], 2013	Türkiye	Cross-sectional study	47.53 ± 13.79	96	2.10	40.60	April 2008 to September 2008	Age, physical function, environment, culture
Liu et al[18], 2011	China	Descriptive research	37.5 ± 9.3	120	52.50	-	September 2008 to March 2010	CD4+ T cell level, CD4/CD8 ratio
Vu et al[19], 2019	Vietnam	Cross-sectional study	49.2 ± 16.0	298	31.40	37.50	October 2018	CD4+ T cell level, CD4/CD8 ratio