Safety and efficacy of different initial doses of lurasidone in the schizophrenia treatment: A multi-center, randomized, open-label study

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World Journal of Psychiatry

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2220-3206

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Psychiatry. Oct 19, 2025; 15(10): 110968
Published online Oct 19, 2025. doi: 10.5498/wjp.v15.i10.110968

Table 2 Exposure and dose modification (full analysis set), mean ± SD

	Lurasidone (40 mg/day), n = 99	Lurasidone (80 mg/day), n = 98	Overall, n = 197
Exposure days on drug (day)	38.6 ± 9.16	32.7 ± 14.55	35.7 ± 12.46
Total exposure level (mg)	2436.4 ± 803.89	2492.0 ± 1147.47	2464.1 ± 987.69
Average daily dose (mg/day)	62.45 ± 13.62	76.72 ± 8.58	69.55 ± 13.43
Dose modification during the second week (%)	60.6	8.2	34.5

Citation: Liu Q, Qian MC, Liu ZF, Dong F, Liu DT, Li ML, Ning YP, Wang XP, Liu TB, Wu Q, Li T, Yu X. Safety and efficacy of different initial doses of lurasidone in the schizophrenia treatment: A multi-center, randomized, open-label study. World J Psychiatry 2025; 15(10): 110968
URL: https://www.wjgnet.com/2220-3206/full/v15/i10/110968.htm
DOI: https://dx.doi.org/10.5498/wjp.v15.i10.110968

Liu Q, Qian MC, Liu ZF, Dong F, Liu DT, Li ML, Ning YP, Wang XP, Liu TB, Wu Q, Li T, Yu X. Safety and efficacy of different initial doses of lurasidone in the schizophrenia treatment: A multi-center, randomized, open-label study. World J Psychiatry 2025; 15(10): 110968 [PMID: 41112599 DOI: 10.5498/wjp.v15.i10.110968]

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