Association of folate metabolism gene polymorphisms with autism susceptibility and symptom severity in the Chinese population

Table 4 Association between folate metabolism gene polymorphism and Childhood Autism Rating Scale

Variables	Model 1		Model 2
	(95%CI)	P value	(95%CI)	P value
MTHFR C667T
Relating to people	0.03 (-0.12 to 0.18)	0.703	0.07 (-0.08 to 0.23)	0.352
limitation	0.12 (-0.08 to 0.31)	0.232	0.13 (-0.07 to 0.33)	0.190
Emotional response	0.11 (-0.07 to 0.28)	0.220	0.07 (-0.10 to 0.25)	0.413
Body use	0.14 (-0.06 to 0.33)	0.167	0.18 (-0.03 to 0.38)	0.087
Object use	0.15 (-0.01 to 0.32)	0.072	0.16 (-0.01 to 0.33)	0.065
Adaptation to change	0.16 (-0.00 to 0.32)	0.054	0.14 (-0.02 to 0.31)	0.081
Visual response	0.05 (-0.09 to 0.18)	0.503	0.09 (-0.05 to 0.22)	0.195
Listening response	0.07 (-0.05 to 0.20)	0.242	0.11 (-0.02 to 0.24)	0.105
Taste, smell, and touch response and use	-0.08 (-0.27 to 0.10)	0.383	-0.08 (-0.26 to 0.11)	0.416
Fear or nervousness	0.02 (-0.15 to 0.19)	0.780	0.02 (-0.15 to 0.20)	0.799
Verbal communication	-0.01 (-0.15 to 0.14)	0.941	0.03 (-0.12 to 0.18)	0.675
Nonverbal communication	-0.12 (-0.28 to 0.04)	0.133	-0.10 (-0.26 to 0.07)	0.248
Activity level	0.02 (-0.09 to 0.13)	0.718	0.01 (-0.10 to 0.12)	0.863
Level and consistency of intellectual response	0.12 (-0.06 to 0.29)	0.189	0.10 (-0.08 to 0.28)	0.269
General impressions	0.12 (-0.06 to 0.29)	0.200	0.13 (-0.06 to 0.31)	0.170
CARS total score	0.89 (-0.59 to 2.37)	0.236	1.07 (-0.42 to 2.57)	0.157
MTRR A66G
Relating to people	0.04 (-0.12 to 0.19)	0.638	0.02 (-0.14 to 0.18)	0.777
limitation	0.04 (-0.16 to 0.23)	0.703	0.05 (-0.16 to 0.25)	0.645
Emotional response	0.15 (-0.02 to 0.32)	0.090	0.21 (0.03-0.39)	0.021
Body use	0.17 (-0.02 to 0.36)	0.084	0.19 (-0.02 to 0.40)	0.072
Object use	0.07 (-0.09 to 0.24)	0.382	0.11 (-0.06 to 0.29)	0.193
Adaptation to change	0.07 (-0.09 to 0.23)	0.381	0.09 (-0.07 to 0.26)	0.272
Visual response	0.04 (-0.09 to 0.17)	0.546	0.04 (-0.10 to 0.17)	0.611
Listening response	0.01 (-0.12 to 0.13)	0.938	-0.01 (-0.14 to 0.12)	0.884
Taste, smell, and touch response and use	0.07 (-0.12 to 0.25)	0.486	0.12 (-0.07 to 0.30)	0.216
Fear or nervousness	0.06 (-0.11 to 0.23)	0.472	0.07 (-0.11 to 0.25)	0.416
Verbal communication	0.12 (-0.02 to 0.26)	0.106	0.12 (-0.02 to 0.27)	0.100
Nonverbal communication	0.19 (0.03-0.35)	0.020	0.20 (0.03-0.36)	0.019
Activity level	0.11 (-0.01 to 0.21)	0.057	0.13 (0.01-0.24)	0.031
Level and consistency of intellectual response	0.02 (-0.15 to 0.20)	0.791	0.01 (-0.18 to 0.18)	0.994
General impressions	0.04 (-0.13 to 0.22)	0.622	0.11 (-0.08 to 0.29)	0.261
CARS total score	1.19 (-0.28 to 2.65)	0.111	1.44 (-0.06 to 2.95)	0.060

Dominant model was used for analysis. Model 1: Unadjusted; model 2: Adjusted for age, gender, ethnicity, parental age at birth, parental education level, mode of delivery, birthweight, premature; CI: Confidence interval; CARS: Childhood Autism Rating Scale.