Association of folate metabolism gene polymorphisms with autism susceptibility and symptom severity in the Chinese population

Table 3 Association between folate metabolism gene polymorphism and Autism Behavior Checklist.

Variables	Model 1		Model 2
	(95%CI)	P value	(95%CI)	P value
MTHFR C667T
Sensory behavior	-0.01 (-1.29 to1.26)	0.984	0.09 (-1.24 to 1.43)	0.891
Social relating	-0.23 (-1.70 to 1.25)	0.762	-0.00 (-1.56 to 1.55)	0.995
Body and object use	-0.27 (-2.01 to 1.47)	0.758	-0.07 (-1.84 to 1.69)	0.935
Language and communication skills	0.75 (-0.64 to 2.14)	0.289	0.67 (-0.81 to 2.15)	0.371
Social and adaptive skills	-0.08 (-1.26 to 1.10)	0.894	-0.11 (-1.32 to 1.11)	0.864
ABC total score	0.05 (-4.62 to 4.73)	0.983	0.44 (-4.49 to 5.37)	0.861
MTRR A66G
Sensory behavior	0.60 (-0.67 to 1.87)	0.350	0.62 (-0.74 to 1.97)	0.368
Social relating	1.93 (0.49-3.37)	0.009	2.27 (0.73-3.81)	0.004
Body and object use	2.01 (0.31-3.72)	0.021	2.48 (0.73-4.23)	0.006
Language and communication skills	-0.29 (-1.69 to 1.10)	0.679	-0.06 (-1.57 to 1.45)	0.936
Social and adaptive skills	1.79 (0.65-2.93)	0.002	1.80 (0.60-3.00)	0.003
ABC total score	6.17 (1.61-10.74)	0.008	7.24 (2.37-12.12)	0.004

Dominant model was used for analysis. Model 1: Unadjusted; model 2: Adjusted for age, gender, ethnicity, parental age at birth, parental education level, mode of delivery, birthweight, premature; CI: Confidence interval; ABC: Autism Behavior Checklist.