Association of folate metabolism gene polymorphisms with autism susceptibility and symptom severity in the Chinese population

Table 2 Association between the genetic model of folate metabolism gene polymorphism and autism spectrum disorder susceptibility

Genetic model		Model 1		Model 2
		OR (95%CI)	P value	AOR (95%CI)	P value
MTHFR C677T
Codominant model	TT vs CC	1.65 (0.78-3.52)	0.190	1.83 (0.83-4.10)	0.138
	CT vs CC	2.03 (1.29-3.24)	0.003	2.38 (1.46-3.92)	< 0.001
Dominant model	TT + CT vs CC	1.95 (1.27-3.01)	0.002	2.28 (1.44-3.65)	< 0.001
Recessive model	TT vs CT + CC	1.22 (0.60-2.55)	0.583	1.33 (0.63-2.82)	0.452
MTRR A66G
Codominant model	GG vs AA	1.70 (0.73-4.04)	0.216	1.71 (0.70-4.29)	0.241
	AG vs AA	1.89 (1.20-2.98)	0.006	1.79 (1.12-2.89)	0.016
Dominant model	GG +AG vs AA	1.86 (1.21-2.87)	0.005	1.74 (1.11-2.73)	0.016
Dominant model	GG vs AG + AA	1.30 (0.57-3.01)	0.534	1.26 (0.54-3.00)	0.594
BHMT G716A
Codominant model	AA vs GG	1.00 (0.45-2.24)	0.995	1.01 (0.42-2.42)	0.981
	AG vs GG	0.87 (0.56-1.35)	0.534	0.85 (0.53-1.35)	0.493
Dominant model	AA+AG vs GG	0.89 (0.58-1.36)	0.585	0.86 (0.55-1.34)	0.505
Recessive model	AA vs AG + GG	1.08 (0.50-2.33)	0.846	1.04 (0.47-2.30)	0.922

Model 1: Unadjusted; model 2: Adjusted for age, gender, ethnicity, parental age at birth, parental education level, mode of delivery, birthweight, premature; AOR: Adjusted odds ratio; CI: Confidence interval; OR: Odds ratio.