Longitudinal trajectories of somatic and cognitive-affective depressive symptoms influence stroke risk across different populations: Three prospective cohort studies

Table 5 Hazard ratios between trajectories of cognitive depressive symptoms and the risk of stroke occurrence

Type	Term	Source	Model	HR	Lower_CI	Upper_CI	SE	Beta	P value
Cognitive_affective_trajectory	Consistently low	Reference
Cognitive_affective_trajectory	Consistently high	CHARLS	1	2.31	1.71	3.11	0.15	5.46	4.82E-08
Cognitive_affective_trajectory	Consistently high	CHARLS	2	2.53	1.87	3.43	0.16	5.98	2.23E-09
Cognitive_affective_trajectory	Consistently high	CHARLS	3	2.06	1.52	2.81	0.16	4.63	3.73E-06
Cognitive_affective_trajectory	Decreasing	CHARLS	1	1.39	0.80	2.42	0.28	1.16	2.47E-01
Cognitive_affective_trajectory	Decreasing	CHARLS	2	1.45	0.83	2.54	0.28	1.32	1.87E-01
Cognitive_affective_trajectory	Decreasing	CHARLS	3	1.26	0.72	2.20	0.28	0.81	4.16E-01
Cognitive_affective_trajectory	Fluctuating	CHARLS	1	1.70	1.29	2.25	0.14	3.73	1.95E-04
Cognitive_affective_trajectory	Fluctuating	CHARLS	2	1.76	1.33	2.33	0.14	3.95	7.83E-05
Cognitive_affective_trajectory	Fluctuating	CHARLS	3	1.63	1.23	2.16	0.14	3.38	7.22E-04
Cognitive_affective_trajectory	Increasing	CHARLS	1	1.74	1.04	2.89	0.26	2.12	3.41E-02
Cognitive_affective_trajectory	Increasing	CHARLS	2	1.84	1.10	3.07	0.26	2.34	1.94E-02
Cognitive_affective_trajectory	Increasing	CHARLS	3	1.53	0.92	2.55	0.26	1.62	1.05E-01
Cognitive_affective_trajectory	Consistently low	Reference
Cognitive_affective_trajectory	Consistently high	ELSA	1	1.44	1.18	1.75	0.10	3.62	2.95E-04
Cognitive_affective_trajectory	Consistently high	ELSA	2	1.28	1.05	1.57	0.10	2.40	1.63E-02
Cognitive_affective_trajectory	Consistently high	ELSA	3	1.25	1.02	1.54	0.10	2.16	3.07E-02
Cognitive_affective_trajectory	Decreasing	ELSA	1	1.67	0.89	3.15	0.32	1.58	1.13E-01
Cognitive_affective_trajectory	Decreasing	ELSA	2	1.51	0.80	2.86	0.33	1.27	2.06E-01
Cognitive_affective_trajectory	Decreasing	ELSA	3	1.47	0.77	2.78	0.33	1.17	2.41E-01
Cognitive_affective_trajectory	Fluctuating	ELSA	1	1.76	1.24	2.49	0.18	3.18	1.48E-03
Cognitive_affective_trajectory	Fluctuating	ELSA	2	1.63	1.15	2.32	0.18	2.72	6.60E-03
Cognitive_affective_trajectory	Fluctuating	ELSA	3	1.58	1.11	2.24	0.18	2.52	1.16E-02
Cognitive_affective_trajectory	Increasing	ELSA	1	1.53	0.49	4.80	0.58	0.74	4.62E-01
Cognitive_affective_trajectory	Increasing	ELSA	2	1.49	0.48	4.68	0.58	0.69	4.93E-01
Cognitive_affective_trajectory	Increasing	ELSA	3	1.43	0.46	4.49	0.58	0.61	5.40E-01
Cognitive_affective_trajectory	Consistently low	Reference
Cognitive_affective_trajectory	Consistently high	HRS	1	2.15	0.30	15.29	1.00	0.77	4.44E-01
Cognitive_affective_trajectory	Consistently high	HRS	2	2.20	0.31	15.71	1.00	0.79	4.30E-01
Cognitive_affective_trajectory	Consistently high	HRS	3	2.04	0.29	14.55	1.00	0.71	4.76E-01
Cognitive_affective_trajectory	Decreasing	HRS	1	2.89	0.40	21.00	1.01	1.05	2.93E-01
Cognitive_affective_trajectory	Decreasing	HRS	2	2.82	0.39	20.51	1.01	1.02	3.07E-01
Cognitive_affective_trajectory	Decreasing	HRS	3	2.54	0.35	18.50	1.01	0.92	3.57E-01
Cognitive_affective_trajectory	Fluctuating	HRS	1	2.53	0.36	18.05	1.00	0.93	3.54E-01
Cognitive_affective_trajectory	Fluctuating	HRS	2	2.77	0.39	19.81	1.00	1.02	3.10E-01
Cognitive_affective_trajectory	Fluctuating	HRS	3	2.56	0.36	18.28	1.00	0.94	3.49E-01
Cognitive_affective_trajectory	Increasing	HRS	1	16.76	2.15	130.96	1.05	2.69	7.19E-03
Cognitive_affective_trajectory	Increasing	HRS	2	15.92	2.03	124.70	1.05	2.63	8.42E-03
Cognitive_affective_trajectory	Increasing	HRS	3	14.67	1.87	114.91	1.05	2.56	1.05E-02

Model 1 explores the unadjusted risk ratios of depressive symptom trajectories with stroke risk. Model 2 adjusts for age, gender, marital status, and education level in addition to the depressive symptom trajectories and stroke risk ratios. Model 3 further adjusts for smoking, alcohol consumption, hypertension, diabetes, and heart problems in addition to age, gender, marital status, education level, and the risk ratios of depressive symptom trajectories with stroke risk. CHARLS: China Health and Retirement Longitudinal Study; ELSA: English Longitudinal Study of Ageing; HRS: Health and Retirement Study; HR: Hazard ratio; CI: Confidence interval.