Longitudinal trajectories of somatic and cognitive-affective depressive symptoms influence stroke risk across different populations: Three prospective cohort studies

Table 4 Hazard ratios between trajectories of somatic depressive symptoms and the risk of stroke occurrence

Type	Term	Source	Model	HR	Lower_CI	Upper_CI	SE	Beta	P value
Somatic_trajectory	Consistently low	Reference
Somatic_trajectory	Consistently high	CHARLS	1	2.53	1.97	3.24	0.13	7.31	2.76E-13
Somatic_trajectory	Consistently high	CHARLS	2	2.65	2.05	3.42	0.13	7.50	6.62E-14
Somatic_trajectory	Consistently high	CHARLS	3	2.16	1.67	2.79	0.13	5.83	5.57E-09
Somatic_trajectory	Fluctuating	CHARLS	1	1.43	1.19	1.72	0.09	3.79	1.54E-04
Somatic_trajectory	Fluctuating	CHARLS	2	1.47	1.22	1.77	0.10	4.03	5.56E-05
Somatic_trajectory	Fluctuating	CHARLS	3	1.35	1.12	1.62	0.10	3.10	1.92E-03
Somatic_trajectory	Consistently low	Reference
Somatic_trajectory	Consistently high	ELSA	1	2.49	1.74	3.56	0.18	4.98	6.42E-07
Somatic_trajectory	Consistently high	ELSA	2	2.18	1.51	3.15	0.19	4.18	2.95E-05
Somatic_trajectory	Consistently high	ELSA	3	1.94	1.34	2.81	0.19	3.51	4.40E-04
Somatic_trajectory	Decreasing	ELSA	1	2.25	1.00	5.08	0.41	1.96	4.97E-02
Somatic_trajectory	Decreasing	ELSA	2	1.81	0.80	4.10	0.42	1.42	1.57E-01
Somatic_trajectory	Decreasing	ELSA	3	1.64	0.72	3.72	0.42	1.17	2.41E-01
Somatic_trajectory	Fluctuating	ELSA	1	1.84	1.51	2.25	0.10	6.07	1.31E-09
Somatic_trajectory	Fluctuating	ELSA	2	1.67	1.37	2.05	0.10	4.97	6.79E-07
Somatic_trajectory	Fluctuating	ELSA	3	1.56	1.27	1.92	0.10	4.26	2.08E-05
Somatic_trajectory	Increasing	ELSA	1	2.60	1.49	4.56	0.29	3.34	8.29E-04
Somatic_trajectory	Increasing	ELSA	2	2.02	1.15	3.54	0.29	2.44	1.47E-02
Somatic_trajectory	Increasing	ELSA	3	1.95	1.11	3.43	0.29	2.33	2.00E-02
Somatic_trajectory	Consistently low	Reference
Somatic_trajectory	Consistently high	HRS	1	2.25	1.89	2.68	0.09	9.09	9.78E-20
Somatic_trajectory	Consistently high	HRS	2	2.22	1.85	2.66	0.09	8.69	3.56E-18
Somatic_trajectory	Consistently high	HRS	3	1.79	1.49	2.15	0.09	6.22	4.84E-10
Somatic_trajectory	Decreasing	HRS	1	1.44	0.92	2.27	0.23	1.58	1.13E-01
Somatic_trajectory	Decreasing	HRS	2	1.46	0.93	2.30	0.23	1.63	1.03E-01
Somatic_trajectory	Decreasing	HRS	3	1.27	0.80	2.00	0.23	1.02	3.06E-01
Somatic_trajectory	Fluctuating	HRS	1	1.54	1.40	1.69	0.05	8.99	2.37E-19
Somatic_trajectory	Fluctuating	HRS	2	1.48	1.34	1.63	0.05	8.02	1.04E-15
Somatic_trajectory	Fluctuating	HRS	3	1.33	1.20	1.46	0.05	5.64	1.69E-08
Somatic_trajectory	Increasing	HRS	1	1.26	0.86	1.85	0.20	1.19	2.36E-01
Somatic_trajectory	Increasing	HRS	2	1.15	0.79	1.69	0.20	0.72	4.69E-01
Somatic_trajectory	Increasing	HRS	3	1.02	0.70	1.50	0.20	0.12	9.05E-01

Model 1 explores the unadjusted risk ratios of depressive symptom trajectories with stroke risk. Model 2 adjusts for age, gender, marital status, and education level in addition to the depressive symptom trajectories and stroke risk ratios. Model 3 further adjusts for smoking, alcohol consumption, hypertension, diabetes, and heart problems in addition to age, gender, marital status, education level, and the risk ratios of depressive symptom trajectories with stroke risk. CHARLS: China Health and Retirement Longitudinal Study; ELSA: English Longitudinal Study of Ageing; HRS: Health and Retirement Study; HR: Hazard ratio; CI: Confidence interval.