Depression and anxiety in patients with endometriosis-associated chronic pain: Neuroimmune mechanisms mediated by inflammatory factors

Table 5 Multiple linear regression analyses for predictors of depression and anxiety

Variable	B	SE	β	P value	95%CI
Dependent variable: BDI-II
Constant	24.63	5.42	-	< 0.001	13.95-35.31
Age	0.06	0.09	0.04	0.497	-0.12 to 0.24
BMI	0.14	0.13	0.06	0.289	-0.12 to 0.40
Disease duration	0.15	0.13	0.07	0.245	-0.10 to 0.40
rASRM stage	0.83	0.62	0.08	0.180	-0.39 to 2.05
Pain severity (VAS)	1.32	0.31	0.27	< 0.001	0.71-1.93
IL-6	0.85	0.32	0.17	0.009	0.22-1.48
IL-1β	0.94	0.69	0.09	0.174	-0.42 to 2.30
TNF-α	0.78	0.31	0.16	0.013	0.17-1.39
CRP	0.21	0.19	0.07	0.269	-0.16 to 0.58
BDNF	-0.26	0.07	-0.21	< 0.001	-0.40 to -0.12
PSQI global	0.49	0.16	0.18	0.003	0.17 to -0.81
R2 = 0.57, adjusted R2 = 0.54, F (11-188) = 22.61, P < 0.001
Dependent variable: STAI-state
Constant	51.84	7.61	-	< 0.001	36.83-66.85
Age	0.03	0.13	0.01	0.831	-0.22 to 0.28
BMI	0.17	0.18	0.06	0.351	-0.19 to 0.53
Disease duration	0.18	0.18	0.06	0.310	-0.17 to 0.53
rASRM stage	0.91	0.87	0.06	0.297	-0.81 to 2.63
Pain severity (VAS)	1.79	0.43	0.30	< 0.001	0.94-2.64
IL-6	0.94	0.45	0.15	0.038	0.05-1.83
IL-1β	0.78	0.97	0.06	0.423	-1.13 to 2.69
TNF-α	0.76	0.43	0.13	0.080	-0.09 to 1.61
CRP	0.12	0.26	0.03	0.646	-0.39 to 0.63
BDNF	-0.32	0.10	-0.21	0.001	-0.52 to -0.12
PSQI Global	0.84	0.23	0.25	< 0.001	0.39-1.29
R2 = 0.51, adjusted R2 = 0.48, F (11-188) = 17.83, P < 0.001

β: Standardized regression coefficient; B: Unstandardized regression coefficient; BDNF: Brain-derived neurotrophic factor; BMI: Body mass index; CI: Confidence interval; CRP: C-reactive protein; IL-6: Interleukin-6; IL-1β: Interleukin-1β; PSQI: Pittsburgh Sleep Quality Index; rASRM: Revised American Society for Reproductive Medicine; SE: Standard error; TNF-α: Tumor necrosis factor-alpha; VAS: Visual analog scale.