Depression and anxiety in patients with endometriosis-associated chronic pain: Neuroimmune mechanisms mediated by inflammatory factors

doi:10.5498/wjp.v15.i10.107147

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World Journal of Psychiatry

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2220-3206

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Psychiatry. Oct 19, 2025; 15(10): 107147
Published online Oct 19, 2025. doi: 10.5498/wjp.v15.i10.107147

Table 4 Correlation matrix of pain severity, inflammatory markers, and psychological symptoms

Variable	1	2	3	4	5	6	7	8	9
1 Pain severity (VAS)	-	-	-	-	-	-	-	-	-
2 BDI-II	0.52^a	-	-	-	-	-	-	-	-
3 STAI-state	0.48^a	0.65^a	-	-	-	-	-	-	-
4 STAI-trait	0.45^a	0.68^a	0.76^a	-	-	-	-	-	-
5 IL-6	0.43^a	0.48^a	0.41^a	0.39^a	-	-	-	-	-
6 IL-1β	0.37^a	0.42^a	0.36^a	0.34^a	0.58^a	-	-	-	-
7 TNF-α	0.40^a	0.45^a	0.38^a	0.36^a	0.62^a	0.54^a	-	-	-
8 CRP	0.35^a	0.40^a	0.33^a	0.31^a	0.49^a	0.42^a	0.45^a	-	-
9 BDNF	-0.38^a	-0.46^a	-0.43^a	-0.44^a	-0.36^a	-0.32^a	-0.34^a	-0.28^a	-

^aP < 0.001.

Values represent Spearman’s correlation coefficients for non-normally distributed variables and Pearson’s correlation coefficients for normally distributed variables. VAS: Visual analog scale; BDI-II: Beck Depression Inventory-II; STAI: State-Trait Anxiety Inventory; IL-6: Interleukin-6; IL-1β: Interleukin-1β; TNF-α: Tumor necrosis factor-alpha; CRP: C-reactive protein; BDNF: Brain-derived neurotrophic factor.

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Citation: Yang FC, Zhou Y, Zhang SY, Ma R. Depression and anxiety in patients with endometriosis-associated chronic pain: Neuroimmune mechanisms mediated by inflammatory factors. World J Psychiatry 2025; 15(10): 107147
URL: https://www.wjgnet.com/2220-3206/full/v15/i10/107147.htm
DOI: https://dx.doi.org/10.5498/wjp.v15.i10.107147

Yang FC, Zhou Y, Zhang SY, Ma R. Depression and anxiety in patients with endometriosis-associated chronic pain: Neuroimmune mechanisms mediated by inflammatory factors. World J Psychiatry 2025; 15(10): 107147 [PMID: 41112598 DOI: 10.5498/wjp.v15.i10.107147]

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