Depression and anxiety in patients with endometriosis-associated chronic pain: Neuroimmune mechanisms mediated by inflammatory factors

Table 2 Psychological assessment scores of the study population, n (%)

Assessment	All participants (n = 200)	With depression (n = 85)	Without depression (n = 115)	P value	With anxiety (n = 102)	Without anxiety (n = 98)	P value
BDI-II, mean ± SD	16.8 ± 10.5	26.4 ± 8.3	9.6 ± 5.1	< 0.001	22.3 ± 10.6	11.0 ± 7.2	< 0.001
Depression severity							< 0.001
Minimal (0-13)	115 (57.5)	0 (0.0)	115 (100.0)	-	38 (37.3)	77 (78.6)	-
Mild (14-19)	43 (21.5)	43 (50.6)	0 (0.0)	-	30 (29.4)	13 (13.3)	-
Moderate (20-28)	28 (14.0)	28 (32.9)	0 (0.0)	-	22 (21.6)	6 (6.1)	-
Severe (29-63)	14 (7.0)	14 (16.5)	0 (0.0)	-	12 (11.8)	2 (2.0)	-
STAI-state, mean ± SD	41.3 ± 12.6	48.7 ± 11.4	35.9 ± 10.4	< 0.001	51.2 ± 9.1	31.0 ± 6.8	< 0.001
STAI-trait, mean ± SD	43.5 ± 11.8	50.2 ± 10.4	38.6 ± 10.2	< 0.001	52.4 ± 8.5	34.3 ± 7.3	< 0.001
PSQI global, mean ± SD	7.9 ± 3.8	9.8 ± 3.5	6.5 ± 3.4	< 0.001	9.3 ± 3.7	6.4 ± 3.3	< 0.001
Poor sleep quality (PSQI > 5)	138 (69.0)	74 (87.1)	64 (55.7)	< 0.001	84 (82.4)	54 (55.1)	< 0.001
PCS, mean ± SD	22.4 ± 12.6	30.1 ± 11.7	16.8 ± 9.9	< 0.001	28.3 ± 12.1	16.3 ± 10.0	< 0.001
EHP-30 core, mean ± SD	42.6 ± 19.7	54.8 ± 16.9	33.8 ± 16.8	< 0.001	51.5 ± 18.2	33.3 ± 16.7	< 0.001

BDI-II: Beck Depression Inventory-II; STAI: State-Trait Anxiety Inventory; PSQI: Pittsburgh Sleep Quality Index; PCS: Pain Catastrophizing Scale; EHP-30: Endometriosis Health Profile-30.