Enhancing schizophrenia treatment efficacy: The combined impact of Yueju pill and olanzapine through quercetin target modulation

Figure 9 Bioinformatics analysis of key signaling pathways involved in schizophrenia relief via Yueju pill combined with olanzapine. A: Simplified flowchart of the bioinformatics analysis for identifying key signaling pathways involved in schizophrenia relief via Yueju pill combined with olanzapine; B: Protein-protein interaction (PPI) network constructed using Cytoscape software based on 36 candidate genes regulated by Yueju pill combined with olanzapine, with larger text and darker background indicating higher degree values; C: Degree values within the PPI network; D-F: Partial results of Gene Ontology analysis for the 36 candidate genes regulated by Yueju pill combined with olanzapine, covering biological processes, molecular functions, and cellular components; G and H: Kyoto Encyclopedia of Genes and Genomes pathway analysis of the 36 candidate genes regulated by Yueju pill combined with olanzapine, presented as a hierarchical tree (G) and a gene heatmap (H), sorted by P adjust values. The size of the circles represents the number of selected genes, and the color indicates the enrichment analysis P value. GO: Gene Ontology; KEGG: Kyoto Encyclopedia of Genes and Genomes; PPI: Protein-protein interaction.