Enhancing schizophrenia treatment efficacy: The combined impact of Yueju pill and olanzapine through quercetin target modulation

Figure 8 Identification of candidate genes and chemical components for schizophrenia relief via Yueju pill combined with olanzapine. A: Flowchart of network pharmacology for identifying candidate genes and chemical components involved in schizophrenia relief via Yueju pill combined with olanzapine; B: Volcano plot based on differential expression analysis from GSE46509; C: Venn diagram showing the intersection of drug targets for effective chemical components of Yueju pill combined with olanzapine and disease targets related to schizophrenia; D: Network interaction map constructed using Cytoscape software for Yueju pill combined with olanzapine, effective components, targets, and disease, with Yueju pill combined with olanzapine on the left; the shared targets of the disease and drugs are shown in the central matrix area, and the effective components of Yueju pill combined with olanzapine are represented by circles. Node size and color intensity indicate the degree value; E: Top 12 active chemical components of Yueju pill combined with olanzapine ranked by degree value; F: Top 12 common targets shared by the disease and the drug components ranked by degree value. TCM: Traditional Chinese medicine.