Metabolic pathway modulation by olanzapine: Multitarget approach for treating violent aggression in patients with schizophrenia

Table 1 Differentially abundant metabolites in patients with schizophrenia with violent aggression

No.	Metabolites	Retention time/minute	m/z	Formula	VIP	P value	Trend	Scan mode
1	Platelet-activating factor	9.44	524.36951	C26 H54 N O7 P	2.09169	0.000	↓	+
2	2-amino-1,3,4-octadecanetriol	6.441	318.29908	C18 H39 N O3	1.88102	0.000	↑	+
3	Palmitic acid	6.402	274.27291	C16 H32 O2	1.86839	0.000	↑	+
4	Cortisol	5.742	363.21555	C21 H30 O5	1.91193	0.000	↑	+
5	Stearic acid	6.99	302.30423	C18 H36 O2	1.59533	0.000	↑	+
6	Hexadecanamide	10.073	256.26277	C16 H33 N O	1.47424	0.000	↑	+
7	Arachidic acid	7.54	330.33567	C20 H40 O2	1.17354	0.000	↑	+
8	N-undecanoylglycine	6.134	266.17185	C13 H25 N O3	1.97952	0.000	↑	+
9	Dihydrosphingosine 1-phosphate	7.693	382.27068	C18 H40 N O5 P	1.37863	0.000	↑	+
10	Palmitoyl ethanolamide	9.734	300.28892	C18 H37 N O2	1.70707	0.000	↑	+
11	D-(+)-pyroglutamic acid	1.01	130.04979	C5 H7 N O3	1.21094	0.000	↓	+
12	Oleoylethanolamide	9.932	326.30444	C20 H39 N O2	1.45824	0.000	↑	+
13	D-erythro-sphingosine 1-phosphate	7.519	380.25492	C18 H38 N O5 P	1.36048	0.000	↑	+
14	Hypoxanthine	1.111	137.04556	C5 H4 N4 O	1.33242	0.000	↓	+
15	Glutamine	0.96	147.07623	C5 H10 N2 O3	1.24123	0.000	↑	+
16	N-undecanoylglycine	6.181	242.17601	C13 H25 N O3	2.20108	0.000	↑	-
17	L-glutamic acid	0.893	146.0449	C5 H9 N O4	1.9134	0.000	↓	-
18	Sphingosine 1-phosphate	7.587	378.24163	C18 H38 N O5 P	1.81005	0.000	↑	-
19	N-phenylacetylglutamine	4.125	263.10371	C13 H16 N2 O4	1.68847	0.000	↑	-
20	D-(-)-fructose	0.853	179.05538	C6 H12 O6	1.63729	0.000	↑	-
21	4-oxoproline	0.968	128.03417	C5 H7 N O3	1.54629	0.000	↓	-
22	L-(+)-lactic acid	1.093	89.02311	C3 H6 O3	1.16621	0.000	↓	-
23	Levothyroxine	6.053	775.68055	C15 H11 I4 N O4	1.51385	0.000	↑	-
24	3-hydroxybutyric acid	1.784	103.03886	C4 H8 O3	1.43635	0.000	↑	-
25	Arachidonic acid	10.197	303.23285	C20 H32 O2	1.12287	0.000	↓	-
26	Cis-5,8,11,14,17-eicosapentaenoic acid	9.785	301.21728	C20 H30 O2	1.09833	0.000	↓	-

“↑” or ”↓” indicates that the metabolite significantly increased or decreased, respectively, in the disease group compared with the control group. VIP: Variable importance in projection.