Relationship between plasma risperidone concentrations and clinical features in chronic schizophrenic patients in China

Table 4 Comparison between adverse drug reaction groups and non-adverse drug reaction group

	Trihexyphenidyl group (n = 10)	No trihexyphenidyl group (n = 40)	P/Z value
Risperidone dose per kg weight2	0.07 ± 0.03	0.06 ± 0.02	0.129
Concentration of risperidone in plasma (ng/mL)1	11.18 ± 11.98	10.90 ± 13.18	0.899
Concentration of 9-hydroxyrisperidone in plasma (ng/mL)2	42.94 ± 26.33	28.32 ± 10.98	0.117
Concentration of risperidon + 9-hydroxyrisperidone in plasma (ng/mL)2	54.12 ± 33.68	39.22 ± 17.52	0.205
Concentration of risperidon + 9-hydroxyrisperidone in plasma/dose1	11.77 ± 5.67	11.65 ± 5.92	0.923
Concentration of risperidon + 9-hydroxyrisperidone in plasma/(dose × kg)1	0.17 ± 0.08	0.19 ± 0.10	0.577
	Laxative drug group (n = 10)	No laxative drug group (n = 40)	P/Z value
Risperidone dose per kg weight2	0.06 ± 0.02	0.06 ± 0.02	0.667
Concentration of risperidone in plasma (ng/mL)1	11.87 ± 14.22	10.71 ± 12.65	0.971
Concentration of 9-hydroxyrisperidone in plasma (ng/mL)1	37.77 ± 28.34	29.61 ± 11.20	0.914
Concentration of risperidon + 9-hydroxyrisperidone in plasma (ng/mL)1	49.64 ± 36.20	40.35 ± 17.15	0.877
Concentration of risperidon + 9-hydroxyrisperidone in plasma/dose1	12.81 ± 6.25	11.39 ± 5.75	0.465
Concentration of risperidon + 9-hydroxyrisperidone in plasma/(dose × kg)1	0.19 ± 0.07	0.18 ± 0.11	0.607

¹Mann-Whitney U-test.

²Student's t-test.