KAT7/HMGN1 signaling epigenetically induces tyrosine phosphorylation-regulated kinase 1A expression to ameliorate insulin resistance in Alzheimer’s disease

Figure 1 KAT7 expression is correlated with Alzheimer’s disease and insulin resistance. A: Immunofluorescence staining of MAP2 in brain tissues form Alzheimer’s disease mice and control. Blue, nuclei; Red, MAP2; B: Western blotting assay to evaluate the expression of MAP2, Aβ, and KAT7 in brain tissues. Histogram of relative protein expression in brain tissues form Alzheimer’s disease mice and control; C: Western blotting assay to evaluate the expression of dual-specificity tyrosine phosphorylation-regulated kinase-1A, IRS-1, and KAT7 in brain tissues of diabetic mice (db/db) and control mice (m/m). Histogram of relative protein expression. ^bP < 0.01. AD: Alzheimer’s disease. DYRK1A: Dual-specificity tyrosine phosphorylation-regulated kinase-1A.