Major depressive disorder is associated with mitochondrial ND6 T14502C mutation in two Han Chinese families

Table 2 Mitochondrial DNA mutations in two Chinese pedigrees with major depressive disorder

Gene	Position	Replacement	Conservation1 (H/B/M/X)	CRS2	NB053	2NB038	Previously reported3
D-loop	73	A to G		A	G	G	Yes
	195	T to C		T		C	Yes
	263	A to G		A	G	G	Yes
	309	C to CCT		C	CCT		Yes
	310	T to C		T	C	TC	Yes
	408	T to A		T	A		Yes
	459	C to T		C	T		Yes
	489	T to C		T	C		Yes
	561	A to C		A	C		Yes
	567	A to ACCCC		A	ACCCC		Yes
	16176	C to T		C		T	Yes
	16223	C to T		C	T	T	Yes
	16232	C to T		C		T	Yes
	16311	T to C		T	C		Yes
	16355	C to T		C		T	Yes
	16362	T to C		T		C	Yes
	16519	T to C		T	C	C	Yes
12S rRNA	750	A to G	A/A/A/-	A	G	G	Yes
	813	A to G	A/A/C/T	A		G	Yes
	884	T to C	T/C/T/C	T	C		Yes
	1438	A to G	A/A/A/G	A	G	G	Yes
16S rRNA	1673	T to C	T/T/T/T	T	C		Yes
	2706	A to G	A/G/A/A	A	G	G	Yes
	3106	CN to C	C/-/T/-	CN	C	C	Yes
	3167	T to TC	T/T/C/C	T	TC		Yes
	3173	G to A	G/A/A/A	G	A		Yes
ND1	4140	C to T		C	T		Yes
ND2	4569	GA to G (Glu34 Lys)	E/E/E/E	GA	G		No
	4573	TA to T (Met35 Lys)	M/M/F/I	TA	T		Yes
	4769	A to G		A	G	G	Yes
	5505	A to G (Ile346Val)	I/L/-/-	A	G		Yes
CO1	5824	G to A		G		A	Yes
	6674	T to C		T		C	Yes
	7028	C to T		C	T	T	Yes
CO2	7975	A to G		A		G	Yes
tRNALys	8296	A to G	A/A/A/A	A		G	Yes
ATP6	8618	T to C (Ile31Thr)	I/F/F/I	T		C	Yes
	8701	A to G (Thr59Ala)	T/S/L/Q	A	G		Yes
	8793	T to C		T	C		Yes
	8860	A to G (Thr112Ala)	T/A/A/T	A	G	G	Yes
	8928	T to C		T		C	Yes
	9027	C to T		C	T		Yes
	9180	A to G		A		G	Yes
CO3	9540	T to C		T	C		Yes
ND3	10289	A to G		A		G	Yes
	10398	A to G (Thr114Ala)	T/T/T/A	A	G		Yes
	10400	C to T		C	T		Yes
ND4	10873	T to C		T	C		Yes
	10908	T to C (Phe50Ser)	F/L/K/H	T		C	Yes
	11581	C to A		C		A	Yes
	11719	G to A		G	A	A	Yes
ND5	12549	C to T		C	T		Yes
	12705	C to T		C	T	T	Yes
	13152	A to G		A	G		Yes
	13422	A to G		A	G		Yes
ND6	14220	A to G		A		G	Yes
	14311	T to C		T		C	Yes
	14431	T to C		T		C	Yes
	14502	T to C (Ile58Val)	I/I/I/I	T	C	C	Yes
CYTB	14766	C to T (Thr7Ile)	T/S/T/S	C	T	T	Yes
	14783	T to C		T	C		Yes
	15040	C to T		C	T		Yes
	15043	G to A		G	A		Yes
	15071	T to C (Tyr109His)	Y/F/F/Y	T	C		Yes
	15301	G to A		G	A		Yes
	15326	A to G (Thr194Ala)	T/M/I/I	A	G	G	Yes
	15514	T to C		T		C	Yes
	15617	G to A (Val291Ile)	V/V/V/V	G	A		Yes
tRNAThr	15900	T to C	T/C/T/T	T		C	Yes

¹Conservation of amino acids for polypeptides or nucleotides for RNAs in human, bovine, mouse, and xenopus laevis.

²Cambridge reference sequence.

³See online mitochondrial genome databases http://www.mitomap.org and http://www.genpat.uu.se/mtDB/.

H: Human; B: Bovine; M: Mouse; X: Xenopus laevis; CRS: Cambridge reference sequence.