Kynurenine pathway of tryptophan metabolism in pathophysiology and therapy of major depressive disorder

doi:10.5498/wjp.v13.i4.141

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World Journal of Psychiatry

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2220-3206

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Psychiatry. Apr 19, 2023; 13(4): 141-148
Published online Apr 19, 2023. doi: 10.5498/wjp.v13.i4.141

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Figure 3 Schematic representation of the proposed role of the kynurenine pathway in the pathophysiology of major depressive disorder. Mutual interactions between serotonergic and glutamatergic functions are indicated by the bidirectional arrows for increased or decreased function. MDD: Major depressive disorder; KMO: Kynurenine monooxygenase; Trp: Tryptophan; IDO: Indoleamine 2,3-dioxygenase; TDO: Tryptophan 2,3-dioxygenase; IFN: Interferon; IL: Interleukin.

Citation: Badawy AAB, Dawood S, Bano S. Kynurenine pathway of tryptophan metabolism in pathophysiology and therapy of major depressive disorder. World J Psychiatry 2023; 13(4): 141-148
URL: https://www.wjgnet.com/2220-3206/full/v13/i4/141.htm
DOI: https://dx.doi.org/10.5498/wjp.v13.i4.141

Badawy AAB, Dawood S, Bano S. Kynurenine pathway of tryptophan metabolism in pathophysiology and therapy of major depressive disorder. World J Psychiatry 2023; 13(4): 141-148 [PMID: 37123095 DOI: 10.5498/wjp.v13.i4.141]

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