Minireviews
Copyright ©The Author(s) 2022.
World J Psychiatry. Dec 19, 2022; 12(12): 1356-1366
Published online Dec 19, 2022. doi: 10.5498/wjp.v12.i12.1356
Table 1 Morphological studies in Parkinson’s disease
Subcortical structures
Ref.
Segmentation methods
Analysis type
Results
Striatum
Geng et al[12], 2006; Pitcher et al[10], 2012; Owens-Walton et al[11], 2018ManualVolumeReduced volume of bilateral caudate and putamen nuclei
Sterling et al[13], 2013Semi-automaticVolumeReduced volume of bilateral caudate and putamen nuclei
Geevarghese et al[15], 2015; Vasconcellos et al[17], 2018; Tanner et al[16], 2017; Melzer et al[30], 2012AutomaticVolumeReduced volume of bilateral caudate nuclei
Oltra et al[35], 2022AutomaticVolumeReduced volume of bilateral caudate nuclei (with RBD)
Lee et al[14], 2014; Garg et al[20], 2015AutomaticVolumeReduced volume of bilateral putamen nuclei
Garg et al[20], 2015AutomaticVolumeReduced volume of right putamen nuclei
Kamps et al[33], 2019AutomaticVolumeReduced volume of right putamen nuclei (with RBD severity)
Kluger et al[34], 2019AutomaticVolumeReduced volume of dorsal striatum (with fatigue)
Messina et al[18], 2011; Menke et al[19], 2014; Nemmi et al[21], 2015; Khan et al[22], 2019; Gong et al[32], 2019AutomaticVolumeNo significant difference in bilateral striatum
Chung et al[31], 2017AutomaticVolumeLocally reduction of right caudate nuclei
Devignes et al[28], 2021AutomaticShapeLocally reduction of left caudate nuclei (with cognition)
Garg et al[20], 2015AutomaticShapeLocally reduction of right putamen nuclei
Gong et al[32], 2019AutomaticShapeLocally reduction of bilateral caudate and right putamen nuclei (with RBD)
Tanner et al[16], 2017AutomaticShapeLocally reduction of the lateral and medial caudate nuclei
Sterling et al[13], 2013Semi-AutomaticShapeLocally reduction of the head and dorsal body of caudate nuclei
Nemmi et al[21], 2015AutomaticShapeLocally reduction of the medial surface of left caudate nuclei (with the right UPDRS)
Tanner et al[16], 2017AutomaticShapeLocally reduction of the medial surface of putamen nuclei
Sterling et al[13], 2013Semi- AutomaticShapeLocally reduction of the caudal and ventrolateral putamen nuclei
Sigirli et al[23], 2021AutomaticShapeLocally reduction of the middle-posterior of right putamen nuclei
Lee et al[14], 2014AutomaticShapeLocally reduction of the posterolateral and ventromedial putamen nuclei
Nemmi et al[21], 2015AutomaticShapeLocally reduction of the lateral and medial posterior putamen nuclei (with UPDRS)
Khan et al[22], 2019AutomaticShapeLocally reduction of the caudal-motor and rostral-motor sub-regions
Thalamus
McKeown et al[43], 2008ManualVolumeNo significant difference
Garg et al[20], 2015AutomaticVolumeSignificant difference
Vasconcellos et al[17], 2018; Mak et al[26], 2014; Sivaranjini et al[27], 2021; Foo et al[45], 2017AutomaticVolumeReduced volume of bilateral thalamus
Niccolini et al[46], 2019AutomaticVolumeReduced volume of bilateral thalamus (with non-motor symptom)
Kamps et al[33], 2019AutomaticVolumeReduced volume of left thalamus (with RBD)
Chen et al[44], 2020AutomaticVolumeIncreased volume (20) of right subnuclei
Chen et al[44], 2020AutomaticVolumeIncreased volume (21), reduced volume (2) of left subnuclei
Kaya et al[40], 2019ManualShapeLocally reduction of the dorsolateral of bilateral STN
Devignes et al[28], 2021AutomaticShapeLocally reduction of right thalamus (with cognition)
Chung et al[31], 2017AutomaticShapeLocally reduction of bilateral thalamus (with cognition)
McKeown et al[43], 2008AutomaticShapeLocally reduction of the dorsal surface of bilateral thalamus
Garg et al[20], 2015AutomaticShapeNet-inward and outward deformation of left thalamus
Hippocampus
Wang et al[55] , 2018AutomaticVolumeReduced volume of right hippocampus
Chen et al[56], 2016AutomaticDensityReduced density of left hippocampus
Geevarghese et al[15], 2015AutomaticVolumeReduced volume of left hippocampus (with cognition)
Lee et al[14], 2014; Tanner et al[16], 2017; Radziunas et al[53], 2018; Melzer et al[30], 2012AutomaticVolumeReduced volume of bilateral hippocampus
Vasconcellos et al[17], 2018AutomaticVolumeReduced volume of bilateral hippocampus (with disease duration)
Camlidag et al[68], 2014; Xu et al[59], 2020AutomaticVolumeReduced volume of bilateral hippocampus (with cognition)
van Mierlo et al[64], 2015AutomaticVolumeReduced volume of bilateral hippocampus (with depression)
Rahayel[63], 2019AutomaticVolumeReduced volume of bilateral hippocampus (with REM-RBD)
Wilson et al[54], 2019AutomaticVolumeReduced volume of bilateral hippocampus (with cognition, motor and disease duration)
Luo et al[60], 2021AutomaticVolumeReduced volume of subfields (with cognition)
Uribe et al[61], 2018AutomaticVolumeReduced volume of subfields, especially CA1
Becker et al[62], 2021AutomaticVolumeReduced volume of CA1 (with cognition)
Xu et al[59], 2020AutomaticVolumeReduced volume of subiculum, CA2/3, CA4, ML and right GC-DG
Park et al[57], 2019AutomaticVolumeVolume asymmetry, especially in CA4-DG and CA2-3
Tanner et al[16], 2017AutomaticShapeLocally reduction in the head and CA1 bilaterally
Devignes et al[28], 2021AutomaticShapeLocally reduction of right hippocampus (with cognition)