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©The Author(s) 2022.
World J Psychiatry. Jan 19, 2022; 12(1): 77-97
Published online Jan 19, 2022. doi: 10.5498/wjp.v12.i1.77
Published online Jan 19, 2022. doi: 10.5498/wjp.v12.i1.77
Figure 2 Hypothesis diagram.
Brain-derived neurotrophic factor (BDNF) deficiency and elevated or chronic neuroinflammation independently confer vulnerability to development of major depressive disorder. BDNF plays a negative regulatory role in resolving neuroinflammation, and high inflammation reduces BDNF expression. BDNF: Brain-derived neurotrophic factor. BDNF: Brain-derived neurotrophic factor.
- Citation: Porter GA, O’Connor JC. Brain-derived neurotrophic factor and inflammation in depression: Pathogenic partners in crime? World J Psychiatry 2022; 12(1): 77-97
- URL: https://www.wjgnet.com/2220-3206/full/v12/i1/77.htm
- DOI: https://dx.doi.org/10.5498/wjp.v12.i1.77