Metabotropic glutamate receptors and nitric oxide in dopaminergic neurotoxicity

Table 2 Main finding on the determination of nitric oxide and its products/metabolites in the rotenone model of neurotoxicity

Ref.	Dose of rotenone	Duration	NO or its products/metabolites	Method of NO determination
Kumar et al[91], 2021	2.0 mg/kg	28	Nitrite	Spectrophotometry
Parkhe et al[92], 2020	2.0 mg/kg	21	Nitrite	Spectrophotometry
Sharma et al[93], 2020	2.0 mg/kg	28	Nitrite	Spectrophotometry
Sun et al[80], 2019	1.5 mg/kg	28	Nitrate/nitrite	NO assay kit
Jayaraj et al[90], 2019	1.5 mg/kg	28	Nitrite	Spectrophotometry
Abdel-Salam et al[89], 2017	1.5 mg/kg × 3	7	Nitrite	Spectrophotometry
Javed et al[86], 2016	2.5 mg/kg	28	Nitrite	Spectrophotometry
Xiong et al[88], 2015	1.5 mg/kg	6	Nitrite	Spectrophotometry
Tapias et al[23], 2014	3.0 mg/kg	Individually1	3-NT (3-nitrotyrosine)	Immunofluorescence
Bashkatova et al[69], 2012	1.5 mg/kg	60	NO (Nitroxyl radical)	EPR
Bashkatova et al[78], 2004	1.5 mg/kg	60	NO (Nitroxyl radical)	EPR
He et al[76], 2003	2 mg/kg × 3	40	3-NT (3-nitrotyrosine)	HPLC

¹Tissue collection was carried out when each individual animal had reached endpoint (when the behavioral phenotype became debilitating, i.e., when akynesia, rigidity, and postural instability were manifested)[23]. NO: Nitric oxide; EPR: Electron paramagnetic resonance; HPLC: High performance liquid chromatography.