Metabotropic glutamate receptors and nitric oxide in dopaminergic neurotoxicity

Table 1 Main findings on metabotropic glutamate receptors involvement in rotenone-induced neurotoxicity

Ref.	Object of study	mGluR type	Ligand
Luo et al[67], 2019	Cell culture; rats	mGluR5	Antagonist MPEP
Bai et al[66], 2018	Cell culture	mGluR5	Agonist CHPG; antagonist MPEP
Xia et al[65], 2015	Cell culture, rats	mGluR5	Antagonist MPEP
Bashkatova et al[69], 2012	Rats	mGluR5	Antagonist MPEP
Sun et al[64], 2012	Cell culture, rats	Group I mGluR	Agonist DHPG
Zhu et al[68], 2012	Cell culture, rats	mGluR5	Antagonist MPEP
Alam et al[70], 2009	Rats	mGluR5	Antagonist MPEP
Jiang et al[63], 2006	Cell culture	Group III mGluR	Agonist L-AP-4

mGluR: Metabotropic glutamate receptors; MPEP: 2-methyl-6-(phenylethynyl) pyridine; CHPG: (RS)-2-chloro-5-hydroxyphenylglycine; DHPG: (S)-3,5-dihydroxyphenylglycine.