Statins as antifungal agents

Table 2 Determined minimal inhibitory concentration values (μg/mL) of different statins against filamentous fungal species

Statin/Species	ATO	FLV	LOV	PRA	ROS	SIM	Ref.
Zygomycetes
Absidia corymbifera	961	> 25-3.6	> 96	> 96	331	961	[19,35]
Absidia glauca	ND	6.25	ND	ND	ND	ND	[35]
Cunninghamella bertholletiae	ND	ND	32-40	ND	ND	ND	[33]
Micromucor ramanniana	ND	> 25	ND	ND	ND	ND	[35]
Mortierella wolfii	> 128	ND	> 128	ND	> 128	> 128	[34]
Mucor circinelloides	ND	ND	5-40	ND	ND	ND	[33]
Mucor circinelloides f. lusitanicus	ND	> 25	ND	ND	ND	ND	[35]
Mucor hiemalis	ND	> 25	ND	ND	ND	ND	[35]
Mucor mucedo	ND	6.25	ND	ND	ND	ND	[35]
Mucor racemosus	ND	25	ND	ND	ND	ND	[35]
Mycotypha africana	8	ND	> 128	ND	8	> 128	[34]
Paecilomyces variotii	32	25	64	> 128	32	8	[29]
Rhizomucor mieheii	> 96	6.25	64-> 128	> 96	331	> 96	[19,32,35]
Rhizomucor pusillus	> 96	3.125	1-3.61	> 96	111	331	[19,32,35]
Rhizopus homothallicus	ND	ND	40-56	ND	ND	ND	[33]
Rhizopus microsporus var. oligosporus	> 96	961	> 96	> 96	> 96	> 96	[19]
Rhizopus oryzae	32-961	2-111	32-128	> 128	> 128	64-> 961	[18,19,29,33,35]
Rhizopus schipperae	ND	> 25	ND	ND	ND	ND	[35]
Rhizopus stolonifer	64		> 128		64	> 128	[34]
Saksenaea vasiformis	ND	> 25	ND	ND	ND	ND	[35]
Syncephalastrum racemosum	32-> 96	331	16-> 96	> 96	32-> 96	8-> 96	[19,34,35]
Ascomycetes
Aspergillus flavus	> 128	128	> 128	> 128	> 128	> 128	[18,29]
Aspergillus fumigatus	64-> 256	2	25	> 128	128-> 256	6.25	[18,29,37]
Aspergillus spp.	ND	ND	16-256	ND	ND	4-256	[36]
Paecilomyces variotii	32	25	64	> 128	32	8	[18]
Heterokontophyta
Pythium insidiosum	ND	16-64	ND	ND	ND	ND	[38]

¹MIC₉₀ value. ATO: Atorvastatin; FLV: Fluvastatin; LOV: Lovastatin; PRA: Pravastatin; ROS: Rosuvastatin; SIM: Simvastatin; ND: Not determined.