Minireviews
Copyright ©The Author(s) 2017.
World J Hypertens. Feb 23, 2017; 7(1): 1-9
Published online Feb 23, 2017. doi: 10.5494/wjh.v7.i1.1
Table 1 Summary of studies evaluating blood pressure thresholds
StudyTypenAge1CAD2DM2CKD2CVA2Baseline DBP3DBP J-curve by outcomeDBP J-curve Nadir3
Studies to target DBP
1967 JAMARCT14351226121CV events and all-cause mortalityNot observed at 92
1970 JAMARCT38051104CV events and all-cause mortalityNot observed at 86
1979 LancetCase-Control16951124MI90
1998 Lancet (HOT)RCT1879062681105CV events; CV and all-cause mortality82-86
Studies in the elderly
1991 JAMA (SHEP)RCT473672510177CVA and other CV events; CV mortalityNot observed at 70
1997 Lancet (Syst- Eur)RCT46957030486CVA and other CV events; all-cause and CV mortalityNot observed at 81
2008 N Engl J Med (HYVET)RCT384584126.8790CVA; all-cause mortality; CV mortality; CVA mortalityNot observed at 84
2016 JAMA (SPRINT)RCT26368025044071All CV events; CV mortality; all-cause mortalityNot observed at 65
Studies in CAD
2005 J Hypertens (ACTION)Post-Hoc7661641001580CV mortality; event or procedure; all-cause mortality; CVA73
2006 Ann Intern Med (INVEST)Post-Hoc2257666100292587All-cause mortality; non-fatal MI or CVA84
2009 J Hypertension (ONTARGET)Post-Hoc255886675372182CV mortality and all CV events75-79
2010 Am J Med (INVEST)Post-Hoc2257666100292587All-cause mortality; non-fatal MI or CVA70-75
2010 Eur Heart J (TNT)Post-Hoc100016010015579All CV events; CV and all-cause mortality81
2010 Circulation (PROVE IT-TIMI)Post-Hoc4162581001811675All-cause mortality and all CV events84-85
2011 Circulation (ONTARGET)Post-Hoc125546675372182CV mortality and all CV events80
2012 Hypertension (SMART)Post-Hoc578857 vs 6560172882CV events and all-cause morality82
2016 Eur Rev MedPharmacol SciRCT369671007105All CV events75-80
2016 Eur Heart J (VALUE)Post-Hoc152446746322087All CV events; all-cause mortality80
Studies in DM
1998 BMJ (UKPDS)RCT11485610094All cause mortalityNot observed at 83
2002 Kidney Int (ABCD)RCT4805910084GFR changes; CV event; retinopathy; neuropathyNot observed at 75
2005 J Am SocNephrol (IDNT)RCT1715592910010087CV events and mortality85
2010 JAMA (INVEST)Post-Hoc6400661001004985All-cause mortality; non-fatal MI or CVASBP nadir 115, but no corresponding DBP nadir reported
2010 N Engl J Med (ACCORD)RCT4733623410076Non-fatal MI or CVA; CV mortalityNot observed at 68
2012 BMJCohort126092671010083All-cause mortality75
Epidemiology studies
1991 BMJ (Framingham)Cohort520930-62CV mortality; non-CV mortality75-79
2003 Ann Intern Med (NHANES II)Cohort783054582All-cause mortality; CV mortality79
2011 J Gen InternMed (NHANES I)Cohort1379225-75All-cause mortality70-79
2014 J Am CollCardiolCohort39841964193024873All-cause mortality; ESRD60-79