Progress in neuregulin/ErbB signaling and chronic heart failure

Table 1 Changes in mRNA levels of chromosome remodeling and histone modification genes in rat cardiomyocytes treated with rhneuregulin-1β

Gene	Fold increase (rhNRG-1β/vehicle)	Biologic process	Ref.
Embryonic ectoderm development (Eed)	1.56	Genetic imprinting, histone methylation	[114]
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 (Smarca4)	1.48	Nucleosome disassembly, methylation-dependent chromatin silencing, ATP-dependent chromatin remodeling	[115]
Jumonji domain containing 6 (Jmjd6)	1.61	Histone H3-R2 demethylation, histone H4-R3 demethylation, histone lysyl 5-hydroxylation	[116,117]
Histone cluster 1, H4b (Hist1h4b)	1.49	Nucleosome assembly	[118]
CSRP2 binding protein (Csrp2bp)	2	Histone acetylation	[119]
H2A histone family, member Z (H2afz)	1.63	Nucleosome assembly	[120]
MYST histone acetyltransferase (monocytic leukemia) 3 (Myst3)	1.48	Chromatin modification, histone acetylation	[121]
Nuclear receptor coactivator 3 (Ncoa3)	2.33	Chromatin modification, histone acetylation	[122]
Nucleophosmin (nucleolar phosphoprotein B23, numatrin) (Nmp1)	1.8	Nucleosome assembly	[123]

NRG: Neuregulin.