Contribution of lysosomal cysteine proteases in cardiac and renal diseases

doi:10.5494/wjh.v2.i3.29

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Jun 23, 2012 (publication date) through May 17, 2024

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World Journal of Hypertension

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2220-3168

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Hypertens. Jun 23, 2012; 2(3): 29-33
Published online Jun 23, 2012. doi: 10.5494/wjh.v2.i3.29

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Figure 1 Roles of cathepsins and cystatin C in the pathogenesis of heart and kidney diseases. A schematic model of cathepsin regulation and function in cardiorenal cells is shown. Tissue and circulating cathepsins (Cats) were used as biomarkers for the diagnosis of cardiorenal disease. Ang I: Angiotensin II; AT1R: Ang II type 1 receptor; IL-1β: Interleukin-1β; TNF-α:Tumor necrosis factor-α; TNFR: TNF-α receptor; ILR: IL-1β receptor; ECM: Extracellular matrix; NADPH: Nicotinamide adenine dinucleotide phosphate.

Citation: Huang D, Li YL, Cheng X. Contribution of lysosomal cysteine proteases in cardiac and renal diseases. World J Hypertens 2012; 2(3): 29-33
URL: https://www.wjgnet.com/2220-3168/full/v2/i3/29.htm
DOI: https://dx.doi.org/10.5494/wjh.v2.i3.29