Bone-specific alkaline phosphatase as a marker of bone formation: Clinical and imaging correlates

doi:10.5493/wjem.121518

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World Journal of Experimental Medicine

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2220-315x

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World J Exp Med. Sep 20, 2026; 16(3): 121518
Published online Sep 20, 2026. doi: 10.5493/wjem.121518

Table 1 Clinical applications of bone-specific alkaline phosphatase

Clinical scenario	BSAP pattern	Clinical interpretation	Utility
Anabolic therapy	↑ Early rise	Increased osteoblast activity	Early response marker
Antiresorptive therapy	↓ Decrease	Reduced bone turnover	Monitor treatment
Fracture healing	↑ Peak at 6-12 weeks	Callus formation	Assess healing
Osteoporosis	↑ Or normal	High vs low turnover	Guide therapy
Paget’s disease	↑↑ Markedly elevated	Excess bone formation	Diagnosis and monitoring
Osteomalacia	↑	Defective mineralization	Diagnostic support
CKD bone disease	↑ or ↓	Turnover differentiation	Clinical decision-making

BSAP: Bone specific alkaline phosphatase; CKD: Chronic kidney disease.

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Citation: Thirunavukkarasu PJ, Gunasekar A, Jeyaraman N, Nallakumarasamy A, Devanand V, Bharadwaj S, Jeyaraman M. Bone-specific alkaline phosphatase as a marker of bone formation: Clinical and imaging correlates. World J Exp Med 2026; 16(3): 121518
URL: https://www.wjgnet.com/2220-315x/full/v16/i3/121518.htm
DOI: https://dx.doi.org/10.5493/wjem.121518

Thirunavukkarasu PJ, Gunasekar A, Jeyaraman N, Nallakumarasamy A, Devanand V, Bharadwaj S, Jeyaraman M. Bone-specific alkaline phosphatase as a marker of bone formation: Clinical and imaging correlates. World J Exp Med 2026; 16(3): 121518 [DOI: 10.5493/wjem.121518]

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