Comparison of ozone administration routes on liver, lung, and brain damage after spinal cord ischemia-reperfusion injury

Table 2 Lung tissue histopathological findings (means ± SEs)

	C group (n = 6)	IR group (n = 6)	IRRO group (n = 6)	IRITO group (n = 6)	IRIPO group (n = 6)	P value1
Interstitial edema	0.50 ± 0.22	1.67 ± 0.33a	0.83 ± 0.31b	0.50 ± 0.22b	0.67 ± 0.21b	0.024
Interstitial hemorrhage	0.17 ± 0.17	1.33 ± 0.21a	0.67 ± 0.33	0.50 ± 0.22b	0.50 ± 0.22b	0.027
Alveolar congestion	0.17 ± 0.17	1.50 ± 0.22a	0.67 ± 0.33b	0.33 ± 0.21b	0.50 ± 0.22b	0.005
Leukocyte infiltration (neutrophil/Lymphocyte)	0.17 ± 0.17	1.67 ± 0.42a	0.83 ± 0.40	0.50 ± 0.22b	0.67 ± 0.33b	0.039
Thickness of the alveolar walls	0.17 ± 0.17	1.50 ± 0.34a	0.67 ± 0.33b	0.33 ± 0.21b	0.50 ± 0.22b	0.014
Total damage score	1.17 ± 0.79	7.33 ± 0.84a	3.50 ± 1.31b	2.17 ± 1.01b	3.00 ± 1.21b	0.008

¹Significance level using the Kruskal-Wallis test; P < 0.05.

^aP < 0.05: Compared to the control group.

^bP < 0.05: Compared to the ischemia-reperfusion group.

C group: Control group; IR group: Ischemia-reperfusion group; IRRO group: Ischemia-reperfusion rectal ozone group; IRITO group: Ischemia-reperfusion intrathecal ozone group; IRIPO group: Ischemia-reperfusion intraperitoneal ozone group.