Evaluation of growth hormone provocative tests in Egyptian children with growth hormone-related short stature

doi:10.5493/wjem.v16.i2.117853

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World Journal of Experimental Medicine

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2220-315x

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Exp Med. Jun 20, 2026; 16(2): 117853
Published online Jun 20, 2026. doi: 10.5493/wjem.v16.i2.117853

Table 3 Optimal cut-off points of peak growth hormone responses to provocative tests, %

Variables	AUC	Cut-off, ng/mL	Sensitivity	Specificity	PPV	NPV	Accuracy
GH provocation test by insulin	0.764	7.54	59.3	91.3	65.6	88.9	74
GH provocation test by clonidine	0.844	8.48	77.8	82.6	76	84	80
GH provocation test by L-DOPA	0.755	4.63	80	70	84.6	66.7	76

AUC: Area under curve; PPV: Positive predictive value; NPV: Negative predictive value; GH: Growth hormone; L-DOPA: Levodopa.

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Citation: Ahmed AEA, Hassan MH, Hamdan RS, Sakhr HM. Evaluation of growth hormone provocative tests in Egyptian children with growth hormone-related short stature. World J Exp Med 2026; 16(2): 117853
URL: https://www.wjgnet.com/2220-315x/full/v16/i2/117853.htm
DOI: https://dx.doi.org/10.5493/wjem.v16.i2.117853

Ahmed AEA, Hassan MH, Hamdan RS, Sakhr HM. Evaluation of growth hormone provocative tests in Egyptian children with growth hormone-related short stature. World J Exp Med 2026; 16(2): 117853 [PMID: 42394781 DOI: 10.5493/wjem.v16.i2.117853]

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