Indocyanine green doped with chitosan nanoparticles based antimicrobial photodynamic therapy in periodontitis patients: A randomized clinical trial

doi:10.5493/wjem.v16.i1.117125

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World Journal of Experimental Medicine

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2220-315x

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Randomized Clinical Trial

Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Exp Med. Mar 20, 2026; 16(1): 117125
Published online Mar 20, 2026. doi: 10.5493/wjem.v16.i1.117125

Table 8 Pairwise comparison within the groups

	aPDT with CNPs-ICG + SRP					Conventional SRP
	Mean	SD	MD	P value		Mean	SD	MD	P value
Baseline	12	1.01	3.73	0.001¹	Baseline	12.2	1.16	3.5	0.001¹
1 month	8.26	0.52			1 month	8.7	0.98
1 month	8.26	0.52	-0.133	0.31	1 month	8.7	0.98	-0.167	0.068
3 months	8.4	0.62		NS	3 months	8.9	0.99		NS
3 months	8.4	0.62	-3.6	0.001¹	3 months	8.9	0.99	-3.33	0.001¹
Baseline	12	1.01			Baseline	12.2	1.16

¹Statistically significant adjusted with Bonferroni correction.

MD: Mean difference; CNPs-ICG: Indocyanine green-doped chitosan nanoparticles; aPDT: Antimicrobial photodynamic therapy; SRP: Scaling and root planning; NS: Not significant.

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Citation: Raj SC, Sen S, Baral D, Mohanty D, Tabassum S, Sil S, Sahu M. Indocyanine green doped with chitosan nanoparticles based antimicrobial photodynamic therapy in periodontitis patients: A randomized clinical trial. World J Exp Med 2026; 16(1): 117125
URL: https://www.wjgnet.com/2220-315x/full/v16/i1/117125.htm
DOI: https://dx.doi.org/10.5493/wjem.v16.i1.117125

Raj SC, Sen S, Baral D, Mohanty D, Tabassum S, Sil S, Sahu M. Indocyanine green doped with chitosan nanoparticles based antimicrobial photodynamic therapy in periodontitis patients: A randomized clinical trial. World J Exp Med 2026; 16(1): 117125 [PMID: 41883436 DOI: 10.5493/wjem.v16.i1.117125]

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