Very low-density lipoprotein and the human health

doi:10.5493/wjem.v16.i1.117024

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World Journal of Experimental Medicine

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2220-315x

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Exp Med. Mar 20, 2026; 16(1): 117024
Published online Mar 20, 2026. doi: 10.5493/wjem.v16.i1.117024

Table 4 Mechanistic links demonstrated in vitro and in vivo for breast cancer and hepatocellular carcinoma

Feature	Breast cancer	Hepatocellular carcinoma
Primary role of VLDL	External lipid fuel for growth and metastasis	External lipid source supporting survival
Key receptors	CD36, VLDLR	VLDLR
Hypoxia involvement	Indirect (metabolic stress adaptation)	Direct via HIF-1α to VLDLR
Demonstrated outcomes	Increased metastasis, invasion, stemness	Increased proliferation, survival
Experimental proof	Cell culture + mouse metastasis models	Cell culture + hypoxia models

VLDL: Very low-density lipoprotein; VLDLR: Very low-density lipoprotein receptor; HIF: Hypoxia-inducible factor.

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Citation: Bharadwaj A, Taneja M, Dubey S, Saxena A. Very low-density lipoprotein and the human health. World J Exp Med 2026; 16(1): 117024
URL: https://www.wjgnet.com/2220-315x/full/v16/i1/117024.htm
DOI: https://dx.doi.org/10.5493/wjem.v16.i1.117024

Bharadwaj A, Taneja M, Dubey S, Saxena A. Very low-density lipoprotein and the human health. World J Exp Med 2026; 16(1): 117024 [PMID: 41883448 DOI: 10.5493/wjem.v16.i1.117024]

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